Collisional activation of [14Pro+2H]2+ clusters: chiral dependence of evaporation and fission processes
| Autor: | Natalya Atlasevich, David E. Clemmer, Stephen J. Valentine, Alison E. Holliday |
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| Rok vydání: | 2012 |
| Předmět: |
Ions
Models Molecular Spectrometry Mass Electrospray Ionization Proline Fission Electrospray ionization Molecular Conformation Stereoisomerism Tandem mass spectrometry Mass spectrometry Dissociation (chemistry) Article Surfaces Coatings and Films Ion chemistry.chemical_compound Crystallography Monomer chemistry Tandem Mass Spectrometry Materials Chemistry Cluster (physics) Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | The journal of physical chemistry. B. 116(26) |
| ISSN: | 1520-5207 |
| Popis: | Ion mobility/mass spectrometry techniques are used to investigate the dissociation of the small proline cluster [14Pro+2H](2+) produced by electrospray ionization. While this cluster is known to prefer heterochiral compositions (i.e., mixed L- and D-compositions, J. Phys. Chem. A, submitted for publication), it is possible to produce homochiral forms by electrospraying solutions containing only L- or D-proline. Differences in the measured cross sections for [14Pro+2H](2+) produced from enantiomerically pure (100% l or 100% d) or racemic (50:50 l/d) solutions indicate that homochiral and heterochiral clusters have different structures. Upon low-energy collisional activation, both the heterochiral and homochiral doubly charged structures evaporate neutral proline monomers, resulting in the formation of [xPro+2H](2+) ions (where x = 9-13). At higher activation energies, there is evidence that these smaller clusters (primarily [10Pro+2H](2+)) fission to produce [xPro+H](+) (where x = 1-6). Analysis of product ion intensities reveals a strong chiral preference associated with fissioning. Products of evaporation also show a chiral dependence but to a lesser extent. |
| Databáze: | OpenAIRE |
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