A Mendelian Randomization Analysis to Expose the Causal Effect of IL-18 on Osteoporosis Based on Genome-Wide Association Study Data
| Autor: | Wenyang Zhou, Yuzhu He, Wenqi Fu, Jiaqian Huang, Tao Fei, Ni Kou, Xiaoxia Ying, Songling Chai, Huiying Liu |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Histology lcsh:Biotechnology Biomedical Engineering Bioengineering Single-nucleotide polymorphism Genome-wide association study 02 engineering and technology 03 medical and health sciences Pleiotropy lcsh:TP248.13-248.65 Internal medicine Mendelian randomization medicine casual effect Original Research business.industry Interleukin-18 Bioengineering and Biotechnology Mendelian Randomization Analysis Odds ratio 021001 nanoscience & nanotechnology Causality 030104 developmental biology genome-wide association studies Osteoporosis Observational study 0210 nano-technology business Biotechnology |
| Zdroj: | Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology, Vol 8 (2020) |
| ISSN: | 2296-4185 |
| Popis: | Accumulating evidence showed that Interleukin (IL) level is associated with Osteoporosis. Whereas, most of these associations are based on observational studies. Thus, their causality was still unclear. Mendelian randomization (MR) is a widely used statistical framework that uses genetic instrumental variables (IVs) to explore the causality of intermediate phenotype with disease. To classify their causality, we conducted a MR analysis to investigate the effect of IL-18 level on the risk of Osteoporosis. First, based on summarized genome-wide association study (GWAS) data, 8 independent IL-18 SNPs reaching genome-wide significance were deemed as IVs. Next, Simple median method was used to calculate the pooled odds ratio (OR) of these 8 SNPs for the assessment of IL-8 on the risk of Osteoporosis. Then, MR-Egger regression was utilized to detect potential bias due to the horizontal pleiotropy of these IVs. As a result of simple median method, we get the SE (−0.001; 95% CI−0.002 to 0; P = 0.042), which means low IL-18 level could increases the risk of the development of Osteoporosis. The low intercept (0; 95% CI −0.001 to 0; P = 0.59) shows there is no bias due to the horizontal pleiotropy of the IVs. |
| Databáze: | OpenAIRE |
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