Toxicities From Antibody-Drug Conjugates

Autor:	Andrew C, Johns, Matthew T, Campbell
Rok vydání:	2022
Předmět:	Cancer Research Immunoconjugates Oncology Neoplasms Humans Antineoplastic Agents
Zdroj:	The Cancer Journal. 28:469-478
ISSN:	1540-336X 1528-9117
DOI:	10.1097/ppo.0000000000000626
Popis:	Antibody-drug conjugates are becoming increasingly important in the treatment of many cancer types. The 3 main structural components-antibody, linker, and payload-each contribute to the toxicity profiles of these drugs. In addition to cytopenias and gastrointestinal adverse effects attributed to the chemotherapy payloads, each drug has specific toxicities that are not commonly described in oncology. Ocular, pulmonary, dermatologic, and neurologic toxicities are particularly nuanced. This review provides a framework for clinicians to analyze current and future antibody-drug conjugates and a description of the unique monitoring, preventive, and supportive care measures for these agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604a15d9811c5e786d4b133f23c90cbc https://doi.org/10.1097/ppo.0000000000000626 Zobrazit plný text záznamu