Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms
| Autor: | Valdeci Da Cunha, Anju Balakrishnan, David E. Gutstein, Jessica J. Moorleghen, Hong Lu, Douglas G. Johns, Alan Daugherty, Debra L. Rateri, Xiaojie Xie, Deborah A. Howatt, Maya Dajee |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Apolipoprotein B macromolecular substances 030204 cardiovascular system & hematology Matrix metalloproteinase Article 03 medical and health sciences Mice 0302 clinical medicine Apolipoproteins E Internal medicine medicine Animals cardiovascular diseases Aortic rupture Relaxin Mice Knockout Messenger RNA Mouse strain biology business.industry Angiotensin II Matrix metalloproteinase 9 General Medicine 030104 developmental biology Endocrinology Matrix Metalloproteinase 9 cardiovascular system biology.protein Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology Aortic Aneurysm Abdominal |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 81(6) |
| ISSN: | 1347-4820 |
| Popis: | Background This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).Methods and Results:Male C57BL/6 or apolipoprotein E-/-mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E-/-mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence. Conclusions MMP-9 deficiency augmented AngII-induced AAA. |
| Databáze: | OpenAIRE |
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