The influence of macro and trace elements on sperm quality
| Autor: | Aleksandra Kasperczyk, Ewa Birkner, Jolanta Zalejska-Fiolka, Michał Dobrakowski, Stanisław Horak |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant medicine.medical_treatment chemistry.chemical_element Semen Calcium medicine.disease_cause Biochemistry Antioxidants Inorganic Chemistry Superoxide dismutase Internal medicine medicine Humans Sulfhydryl Compounds chemistry.chemical_classification biology Chemistry Glutathione peroxidase Albumin Spermatozoa Trace Elements Oxidative Stress Endocrinology Metals biology.protein Cytokines Molecular Medicine Selenium Oxidative stress |
| Zdroj: | Journal of Trace Elements in Medicine and Biology. 30:153-159 |
| ISSN: | 0946-672X |
| DOI: | 10.1016/j.jtemb.2014.12.007 |
| Popis: | The aim of this study was to examine the association between combined concentrations of macro and trace elements and markers of oxidative stress and antioxidative defense system function together with selected cytokine levels. Based on the combined medians of the seminal plasma levels of calcium, magnesium, zinc, copper, iron, and selenium, the study subjects (88 fertile male volunteers) were divided into the following two subgroups: the Me-L group (low level of metals) and the Me-H group (high level of metals). There was a tendency toward reduced motility in the Me-H group compared to that in the Me-L group. The total protein, albumin, and total oxidation status (TOS) levels were significantly higher in the Me-H group than in the Me-L group. The total superoxide dismutase (SOD), Mn-SOD, and CuZn-SOD, activity in spermatozoa were significantly lower in the Me-H group than in the Me-L group. In seminal plasma, the Mn-SOD activity was significantly higher in the Me-H group, whereas the CuZn-SOD activity was significantly lower. Additionally, the activity levels of glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were lower in the Me-H group. The medians of IL-1β, IL-10, and IL-12 were significantly higher in the Me-H group than in the Me-L group, whereas the medians of IL-2, IL-5, and IL-13 were significantly lower. Higher levels of macro and trace elements in the seminal plasma of fertile males may be associated with decreased motility. Higher levels of the examined metals are associated with elevated oxidative stress accompanied by decreased activities of some of the antioxidant enzymes and increased pro-inflammatory cytokine levels. |
| Databáze: | OpenAIRE |
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