Renal Cell Carcinoma: The Translation of Molecular Biology Into New Treatments, New Patient Outcomes, and Nursing Implications
| Autor: | Robert A. Figlin, Nancy Moldawer |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Niacinamide
Sorafenib Oncology medicine.medical_specialty Indoles Bevacizumab Pyridines Angiogenesis Inhibitors Antineoplastic Agents Disease Antibodies Monoclonal Humanized urologic and male genital diseases Nephrectomy Rare Diseases Nursing Risk Factors Renal cell carcinoma Internal medicine Sunitinib medicine Humans Pyrroles Disease management (health) Carcinoma Renal Cell Molecular Biology Protein Kinase Inhibitors Neoplasm Staging Sirolimus business.industry Incidence Phenylurea Compounds Benzenesulfonates Oncology Nursing Antibodies Monoclonal Interferon-alpha Prognosis medicine.disease female genital diseases and pregnancy complications Temsirolimus Treatment Outcome Localized disease Catheter Ablation Interleukin-2 Diffusion of Innovation business medicine.drug |
| Zdroj: | Oncology Nursing Forum. 35:699-708 |
| ISSN: | 1538-0688 0190-535X |
| DOI: | 10.1188/08.onf.699-708 |
| Popis: | Purpose/objectives To provide an overview of the current knowledge and treatment options for renal cell carcinoma (RCC). Data sources Published articles, published abstracts, online databases, and package inserts. Data synthesis Researchers have an increased understanding of the genetic and prognostic risk factors associated with RCC. Most patients with this rare type of cancer have or will develop metastasis. Nephrectomy treats localized disease and cytokine therapy was the previous standard for metastatic disease, but newly approved targeted agents, such as sorafenib, temsirolimus, and sunitinib, as well as investigational agents such as bevacizumab, are improving patient outcomes. Conclusions Understanding the biologic basis of RCC has led to therapies that are transforming the goals for treatment outcomes in patients with metastatic disease and increasing time to progression with manageable side effects. Implications for nursing Counseling patients and managing treatment-related side effects of therapy are critical interventions for healthcare professionals caring for patients with RCC. Evolving treatments for metastatic disease are providing better options for patients and changing disease management. |
| Databáze: | OpenAIRE |
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