Association of Proteins Modulating Immune Response and Insulin Clearance During Gestation with Antenatal Complications in Patients with Gestational or Type 2 Diabetes Mellitus
Autor: | Tatiana Mayatskaya, Lubov Kharitonova, Iveta Gribova, Anna L. Kaysheva, Olga Papysheva, Anna Krasheninnikova, Arthur T. Kopylov, Galina Kotaysch, Sergey G. Morozov |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
0301 basic medicine medicine.medical_specialty endocrine system diseases type 2 diabetes mellitus medicine.medical_treatment immunoglobulins 030209 endocrinology & metabolism Models Biological Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Insulin resistance Pregnancy Diabetes mellitus Internal medicine insulin resistance Cluster Analysis Humans Insulin Medicine lcsh:QH301-705.5 diabetic fetopathy business.industry Immunity Infant Newborn Proteins Type 2 Diabetes Mellitus General Medicine medicine.disease gestational diabetes mellitus Gestational diabetes carnosine Diabetes Gestational Gene Ontology 030104 developmental biology Diabetes Mellitus Type 2 ROC Curve lcsh:Biology (General) Calibration Gestation Female Diabetic Fetopathy business Complication |
Zdroj: | Cells, Vol 9, Iss 1032, p 1032 (2020) Cells Volume 9 Issue 4 |
ISSN: | 2073-4409 |
Popis: | Background: The purpose of the study is to establish and quantitatively assess protein markers and their combination in association with insulin uptake that may be have value for early prospective recognition of diabetic fetopathy (DF) as a complication in patients with diabetes mellitus during gestation. Methods: Proteomic surveying and accurate quantitative measurement of selected proteins from plasma samples collected from the patients with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) who gave birth of either healthy or affected by maternal diabetes newborns was performed using mass spectrometry. Results: We determined and quantitatively measured several proteins, including CRP, CEACAM1, CNDP1 and Ig-family that were significantly differed in patients that gave birth of newborns with signs of DF. We found that patients with newborns associated with DF are characterized by significantly decreased CEACAM1 (113.18 ± 16.23 ng/mL and 81.09 ± 10.54 ng/mL in GDM and T2DM, p < 0.005) in contrast to control group (515.6 ± 72.14 ng/mL, p < 0.005). On the contrary, the concentration of CNDP1 was increased in DF-associated groups and attained 49.3 ± 5.18 ng/mL and 37.7 ± 3.34 ng/mL (p < 0.005) in GDM and T2DM groups, respectively. Among other proteins, dramatically decreased concentration of IgG4 and IgA2 subclasses of immunoglobulins were noticed. Conclusion: The combination of the measured markers may assist (AUC = 0.893 (CI 95%, 0.785&ndash 0.980) in establishing the clinical finding of the developing DF especially in patients with GDM who are at the highest risk of chronic insulin resistance. |
Databáze: | OpenAIRE |
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