Association of Proteins Modulating Immune Response and Insulin Clearance During Gestation with Antenatal Complications in Patients with Gestational or Type 2 Diabetes Mellitus

Autor: Tatiana Mayatskaya, Lubov Kharitonova, Iveta Gribova, Anna L. Kaysheva, Olga Papysheva, Anna Krasheninnikova, Arthur T. Kopylov, Galina Kotaysch, Sergey G. Morozov
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
0301 basic medicine
medicine.medical_specialty
endocrine system diseases
type 2 diabetes mellitus
medicine.medical_treatment
immunoglobulins
030209 endocrinology & metabolism
Models
Biological
Gastroenterology
Article
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Pregnancy
Diabetes mellitus
Internal medicine
insulin resistance
Cluster Analysis
Humans
Insulin
Medicine
lcsh:QH301-705.5
diabetic fetopathy
business.industry
Immunity
Infant
Newborn
Proteins
Type 2 Diabetes Mellitus
General Medicine
medicine.disease
gestational diabetes mellitus
Gestational diabetes
carnosine
Diabetes
Gestational
Gene Ontology
030104 developmental biology
Diabetes Mellitus
Type 2
ROC Curve
lcsh:Biology (General)
Calibration
Gestation
Female
Diabetic Fetopathy
business
Complication
Zdroj: Cells, Vol 9, Iss 1032, p 1032 (2020)
Cells
Volume 9
Issue 4
ISSN: 2073-4409
Popis: Background: The purpose of the study is to establish and quantitatively assess protein markers and their combination in association with insulin uptake that may be have value for early prospective recognition of diabetic fetopathy (DF) as a complication in patients with diabetes mellitus during gestation. Methods: Proteomic surveying and accurate quantitative measurement of selected proteins from plasma samples collected from the patients with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) who gave birth of either healthy or affected by maternal diabetes newborns was performed using mass spectrometry. Results: We determined and quantitatively measured several proteins, including CRP, CEACAM1, CNDP1 and Ig-family that were significantly differed in patients that gave birth of newborns with signs of DF. We found that patients with newborns associated with DF are characterized by significantly decreased CEACAM1 (113.18 ±
16.23 ng/mL and 81.09 ±
10.54 ng/mL in GDM and T2DM, p <
0.005) in contrast to control group (515.6 ±
72.14 ng/mL, p <
0.005). On the contrary, the concentration of CNDP1 was increased in DF-associated groups and attained 49.3 ±
5.18 ng/mL and 37.7 ±
3.34 ng/mL (p <
0.005) in GDM and T2DM groups, respectively. Among other proteins, dramatically decreased concentration of IgG4 and IgA2 subclasses of immunoglobulins were noticed. Conclusion: The combination of the measured markers may assist (AUC = 0.893 (CI 95%, 0.785&ndash
0.980) in establishing the clinical finding of the developing DF especially in patients with GDM who are at the highest risk of chronic insulin resistance.
Databáze: OpenAIRE
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