Synthesis and Functionalization of Tertiary Propargylic Boronic Esters by Alkynyllithium-Mediated 1,2-Metalate Rearrangement of Borylated Cyclopropanes

Autor:	Tereza Pavlíčková, Yannick Stöckl, Ilan Marek
Rok vydání:	2022
Předmět:	Cyclopropanes Organic Chemistry Esters Physical and Theoretical Chemistry Biochemistry Boron
Zdroj:	Organic letters. 24(48)
ISSN:	1523-7052
Popis:	Implementing the use of alkynyllithium reagents in a stereospecific 1,2-metalate rearrangement-mediated ring opening of polysubstituted cyclopropyl boronic esters provides a variety of tertiary pinacol boranes bearing adjacent tertiary or quaternary carbon stereocenters with high levels of diastereomeric purity. The potential of this strategy was demonstrated through a selection of α- and γ-functionalization of the propargyl boronic esters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6041fdd8ab527d33440bd1d49bdcbd6e https://pubmed.ncbi.nlm.nih.gov/36446049 Zobrazit plný text záznamu