Clinical effectiveness and speed of response of electroconvulsive therapy in treatment‐resistant schizophrenia
| Autor: | Christopher Yi Wen Chan, Mythily Subramaniam, Phern-Chern Tor, Jianlin Liu, Chao Xu Peh, Edimansyah Abdin, Esmond Seow |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Global Assessment of Functioning behavioral disciplines and activities Young Adult 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy mental disorders Brief Psychiatric Rating Scale medicine Humans Electroconvulsive Therapy Retrospective Studies Psychiatric Status Rating Scales business.industry General Neuroscience Montreal Cognitive Assessment Retrospective cohort study General Medicine Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Treatment Outcome Neurology Schizophrenia Quality of Life Clinical Global Impression Physical therapy Female Neurology (clinical) business 030217 neurology & neurosurgery Diagnosis of schizophrenia |
| Zdroj: | Psychiatry and Clinical Neurosciences. 73:416-422 |
| ISSN: | 1440-1819 1323-1316 |
| Popis: | Aim Although electroconvulsive therapy (ECT) has been shown to be efficacious for patients with treatment-resistant schizophrenia, there has been limited evidence on the rate of response, cognition, and quality-of-life outcomes. The primary aims of the present study were thus to examine the effectiveness and speed of response to ECT in a naturalistic retrospective cohort in patients with treatment-resistant schizophrenia. Methods We performed a retrospective database analysis. The primary effectiveness outcome was defined as an improvement of ≥40% from pretreatment scores based on the Brief Psychiatric Rating Scale (BPRS) Psychotic Symptom subscale. Data were included for analysis for all patients with a primary DSM-5 diagnosis of schizophrenia that was treatment-resistant and who had had an acute course of ECT initiated for the treatment of schizophrenia between 1 July 2016 and 1 December 2016. Results A total of 50 inpatients were included for analysis. The present study revealed that 50% of patients showed at least a 40% reduction in BPRS Psychotic Symptom subscale scores after completion of ECT and that 16.7% of patients responded after the first three sessions, 39.3% after six sessions, 46.4% after nine sessions, and 50% after 12 sessions. The greatest improvement in BPRS scores was between the third and sixth ECT sessions. BPRS scores, Clinical Global Impression, Montreal Cognitive Assessment, and Global Assessment of Functioning showed significant improvement. There was no significant difference in quality-of-life outcomes. Conclusion Utilizing modern techniques in treatment-resistant schizophrenia, this study demonstrates the real-world effectiveness and rate of response of patients receiving ECT. |
| Databáze: | OpenAIRE |
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