Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses
| Autor: | Parikshit Bagchi, Anupam Mukherjee, Satarupa Mullick Bagchi, Anwesha Banerjee, Nikita Nanaware |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
autophagy
Antibody Dependent Enhancement (ADE) Viral pathogenesis viruses Review Dengue virus Antibodies Viral Virus Replication medicine.disease_cause Microbiology Virus Dengue fever Dengue Flaviviridae Viral envelope Virology medicine Humans Dengue genome Life Cycle Stages Host Microbial Interactions biology viral pathogenesis apoptosis biology.organism_classification medicine.disease host immune response QR1-502 Infectious Diseases Viral replication inflammation cytokine storm RNA Viral viral replication Viral disease |
| Zdroj: | Viruses, Vol 13, Iss 1967, p 1967 (2021) Viruses |
| ISSN: | 1999-4915 |
| Popis: | Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one of the prominent public health problems in tropical and subtropical regions with no effective vaccines. Every year around 400 million people get infected by the Dengue virus, with a mortality rate of about 20% among the patients with severe dengue. The Dengue virus belongs to the Flaviviridae family, and it is an enveloped virus with positive-sense single-stranded RNA as the genetic material. Studies of the infection cycle of this virus revealed potential host targets important for the virus replication cycle. Here in this review article, we will be discussing different stages of the Dengue virus infection cycle inside mammalian host cells and how host proteins are exploited by the virus in the course of infection as well as how the host counteracts the virus by eliciting different antiviral responses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|