Microcystin-LR retards gonadal maturation through disrupting the growth hormone/insulin-like growth factors system in zebrafish
Autor: | Ping Xie, Jie Hou, Yujing Su, Gu Zemao, Jun Chen, Honghui Guo, Li Li, Wang Lin |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine Health Toxicology and Mutagenesis medicine.medical_treatment Microcystin-LR 010501 environmental sciences 01 natural sciences chemistry.chemical_compound Sexual maturity Enzyme Inhibitors Insulin-Like Growth Factor I Zebrafish media_common biology Reproduction Brain General Medicine Spermatozoa Pollution Liver Female Development of the gonads endocrine system medicine.medical_specialty Microcystins media_common.quotation_subject Cyanobacteria 03 medical and health sciences Somatomedins Internal medicine medicine Animals Gonads 0105 earth and related environmental sciences Life Cycle Stages Insulin Ovary Insulin-like growth factor 2 receptor Public Health Environmental and Occupational Health Environmental Exposure biology.organism_classification Sperm 030104 developmental biology Endocrinology chemistry Growth Hormone Marine Toxins Water Pollutants Chemical |
Zdroj: | Ecotoxicology and Environmental Safety. 139:27-35 |
ISSN: | 0147-6513 |
Popis: | Recent studies have documented that microcystins (MCs) have potential toxic effects on growth and reproduction in fish. However, no systematic data exist on whether MCs cause gonadal development retardation through disrupting the growth hormone/insulin-like growth factors (GH/IGFs) system. To this end, zebrafish hatchlings (5 d post-fertilization) were exposed to 0, 0.3, 3 and 30µg/L microcystin-LR (MC-LR) for 90 d until they reached sexual maturity. Life-cycle exposure to MC-LR caused delayed ovarian maturation and sperm development along with ultrapathological lesions in the brain and liver. Moreover, the retarded gonadal development was accompanied by an inhibition of the GH/IGFs system, which was characterized by significant decreases in the transcriptional levels of brain gh (males only), hepatic igf2a and igf2b as well as gonadal igf1 (males only), igf3 and igf2r. These findings for the first time point to the influence of MC-LR on fish gonadal development via the GH/IGFs system. Also, sex-differential impairments suggested that gonadal development of males is more vulnerable than that of female to MC-LR. Our results provide evidence that MC-LR at environmentally relevant concentrations is able to induce impairments on fish gonadal development. |
Databáze: | OpenAIRE |
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