Human embryonic stem cell-derived melanocytes exhibit limited immunogenicity
| Autor: | Jinqi Wang, Haozhen Lv, Xuanhao Zeng, Yating Liu, Qi Zhang, Jinhua Xu, Weiling Lian, Kelu Wei |
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| Rok vydání: | 2021 |
| Předmět: |
Allogeneic transplantation
business.industry Immunogenicity Human Embryonic Stem Cells Biophysics Cell Differentiation Cell Biology Vitiligo Regenerative Medicine medicine.disease Biochemistry Embryonic stem cell Regenerative medicine Coculture Techniques Transplantation Immune system Allogeneic Lymphocyte Cancer research Humans Melanocytes Medicine business Molecular Biology Cells Cultured |
| Zdroj: | Biochemical and Biophysical Research Communications. 573:151-157 |
| ISSN: | 0006-291X |
| Popis: | Although surgical interventions have become optional for refractory vitiligo, grafting related injuries is inevitable. Embryonic stem cell (ESC) derivatives can be used in transplantation to address this issue, but the immune rejection due to allogeneic transplantation is of great concern. To investigate the immunogenicity of ESC derived melanocytes (ES-MC), we established a co-culture system of ES-MC and allogeneic PBMC. The results showed that ES-MC were similar to human primary melanocytes, with low expression of immune related molecules, and limited capability of stimulating allogeneic lymphocytes in vitro. Taken together, our findings confirm that ES-MC are of limited immunogenicity, providing new insights into the application of ES-MC in the regenerative medicine such as treating vitiligo. |
| Databáze: | OpenAIRE |
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