Diffuse Brain Hypoperfusion in Advanced Leukoencephalopathy with Calcifications and Cysts
| Autor: | Alessandra Vella, Ilaria Bartolomei, Antonio Ciccarone, Fabrizio Salvi, Emanuele Bartolini, Andrea Bianchi, Mario Mascalchi, Lapo Sali |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Brain Ischemia 030218 nuclear medicine & medical imaging White matter Leukoencephalopathy 03 medical and health sciences 0302 clinical medicine Leukoencephalopathies Humans Medicine Cerebral atrophy Cysts business.industry Rehabilitation Rosenthal fiber Calcinosis Middle Aged medicine.disease Magnetic Resonance Imaging Subcortical gray matter medicine.anatomical_structure Gliosis Cerebral blood flow Cerebrovascular Circulation Hemosiderin Surgery Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | ResearcherID Publons |
| ISSN: | 1052-3057 |
| DOI: | 10.1016/j.jstrokecerebrovasdis.2016.04.030 |
| Popis: | Leukoencephalopathy with calcifications and cysts (LCC) is an uncommon condition of unknown etiology occurring in children and adults. Pathological findings include obliterative hyalinosis of the small vessels, myelin loss, intense gliosis, Rosenthal fiber formation, microcalcifications, and hemosiderin deposits. Herein we report a 55-year-old man with LCC documented 10 years ago, in whom we examined brain perfusion by pseudocontinuous arterial spin labeling technique. We demonstrated diffused hypoperfusion of the affected white matter (WM) and of the subcortical gray matter (GM) and cortical GM in the patient in comparison to a group of healthy control subjects, using both qualitative evaluation and region of interest analysis. WM and subcortical GM hypoperfusion reflects the known distribution of LCC microangiopathy. We speculate that cortical hypoperfusion may be related to cerebral atrophy or may reflect deafferentation secondary to severe leukoencephalopathy, and may possibly contribute to severe motor and cognitive impairment. Further studies addressing cerebral blood flow in LCC are necessary. |
| Databáze: | OpenAIRE |
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