Alpha 1-microglobulin is mitogenic for guinea pig lymphocytes
| Autor: | L. Lögdberg, E. M. Shevach, B. Åkerström |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Beta-2 microglobulin Lymphocyte Immunology Guinea Pigs Alpha (ethology) Spleen Stimulation General Medicine Biology Lymphocyte Activation Guinea pig medicine.anatomical_structure Endocrinology Species Specificity Internal medicine Histocompatibility Antigens Blood plasma Alpha-Globulins medicine Mesenteric lymph nodes Animals Antigens Mitogens |
| Zdroj: | Scandinavian journal of immunology. 24(5) |
| ISSN: | 0300-9475 |
| Popis: | Guinea pig alpha 1-microglobulin (alpha 1-m) was found to exert mitogenic effects on guinea pig lymphocytes, i.e. peritoneal exudate lymphocytes (PEL) or T lymphocytes from regional or mesenteric lymph nodes (LNL). On the other hand, spleen T lymphocytes did not respond to alpha 1-m. Stimulation of LNL required the presence of accessory cells. The stimulatory effect was strain-specific: alpha 1-m clearly induced proliferation of lymphocytes from Strain 2 guinea pigs, whereas Strain 13 lymphocytes responded poorly or not at all. Moreover, alpha 1-m inhibited antigen-driven proliferation of guinea pig lymphocytes. None of the effects described were species-specific, e.g. human alpha 1-m exerted similar effects on the guinea pig lymphocytes. These data indicate that alpha 1-m may be involved in the regulation of lymphocyte activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text