Influence of Chronic Ocular Hypertension on Emmetropia: Refractive, Structural and Functional Study in Two Rat Models
| Autor: | David Garcia-Herranz, Luis E. Pablo, Maria Jesus Rodrigo, Teresa Martinez-Rincon, Manuel Subias, Irene Bravo-Osuna, Silvia Mendez-Martinez, Rocío Herrero-Vanrell, Elena García-Martín, Julian García Feijoo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Refractive error
medicine.medical_specialty Intraocular pressure genetic structures Ocular hypertension Glaucoma Emmetropia Article chemistry.chemical_compound Ophthalmology medicine refractive error myopia medicine.diagnostic_test business.industry Retinal General Medicine medicine.disease eye diseases neuroretina glaucoma chemistry Cohort Medicine sense organs business Electroretinography intraocular pressure |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 16 Zaguán. Repositorio Digital de la Universidad de Zaragoza Universitat Politècnica de Catalunya (UPC) Journal of Clinical Medicine, Vol 10, Iss 3697, p 3697 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10163697 |
| Popis: | Chronic ocular hypertension (OHT) influences on refraction in youth and causes glaucoma in adulthood. However, the origin of the responsible mechanism is unclear. This study analyzes the effect of mild-moderate chronic OHT on refraction and neuroretina (structure and function) in young-adult Long-Evans rats using optical coherence tomography and electroretinography over 24 weeks. Data from 260 eyes were retrospectively analyzed in two cohorts: an ocular normotension (ONT) cohort (< 20 mmHg) and an OHT cohort (> 20 mmHg), in which OHT was induced either by sclerosing the episcleral veins (ES group) or by injecting microspheres into the anterior chamber. A trend toward emmetropia was found in both cohorts over time, though it was more pronounced in the OHT cohort (p < 0.001), especially in the ES group (p = 0.001) and males. IOP and refraction were negatively correlated at week 24 (p = 0.010). The OHT cohort showed early thickening in outer retinal sectors (p < 0.050) and the retinal nerve fiber layer, which later thinned. Electroretinography demonstrated early supranormal amplitudes and faster latencies that later declined. Chronic OHT accelerates emmetropia in Long–Evans rat eyes towards slowly progressive myopia, with an initial increase in structure and function that reversed over time. |
| Databáze: | OpenAIRE |
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