Model evaluation of target product profiles of an infant vaccine against respiratory syncytial virus (RSV) in a developed country setting
| Autor: | Timothy M. Kinyanjui, D J Nokes, Sompob Saralamba, Wirichada Pan-Ngum, Sylvia Taylor, Lisa J. White |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Burden of disease
lcsh:Immunologic diseases. Allergy medicine.medical_specialty Rsv vaccine RJ viruses 030231 tropical medicine Respiratory tract disease medicine.disease_cause Virus 03 medical and health sciences 0302 clinical medicine Epidemiology medicine UK 030212 general & internal medicine RSV vaccination strategies General Veterinary General Immunology and Microbiology business.industry Public Health Environmental and Occupational Health RSV Transmission model 3. Good health Infectious Diseases Respiratory syncytial virus (RSV) Regular paper Immunology Molecular Medicine business lcsh:RC581-607 Developed country RC |
| Zdroj: | Vaccine: X, Vol 4, Iss, Pp-(2020) Kinyanjui, T M, Pan-Ngum, W, Saralamba, S, Taylor, S & Nokes, D J 2020, ' Model evaluation of target product profiles of an infant vaccine against respiratory syncytial virus (RSV) in a developed country setting ', Vaccine . https://doi.org/10.1016/j.jvacx.2020.100055 Vaccine: X |
| ISSN: | 2590-1362 |
| DOI: | 10.1016/j.jvacx.2020.100055 |
| Popis: | Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in children worldwide and is a significant cause of hospital admissions in young children in England. No RSV vaccine has been licensed but a number are under development. In this work, we present two structurally distinct mathematical models, parameterized using RSV data from the UK, which have been used to explore the effect of introducing an RSV paediatric vaccine to the National programme. We have explored different vaccine properties, and dosing regimens combined with a range of implementation strategies for RSV control. The results suggest that vaccine properties that confer indirect protection have the greatest effect in reducing the burden of disease in children under 5 years. The findings are reinforced by the concurrence of predictions from the two models with very different epidemiological structure. The approach described has general application in evaluating vaccine target product profiles. Keywords: RSV, Transmission model, RSV vaccination strategies, UK |
| Databáze: | OpenAIRE |
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