Improvement of cardiometabolic markers after fish oil intervention in young Mexican adults and the role of PPARα L162V and PPARγ2 P12A
| Autor: | Laura M. Gosoniu, Isabel Rubio-Aliaga, Eli Gámez-Valdez, Yanelli Rodríguez-Carmona, Brianda Hernández-Morán, Ivan Montoliu, Philippe Valet, Diana C. Soria-Contreras, Diego Martínez-Conde, Ricardo Márquez-Velasco, Marisol Ramírez-Solano, Martin Kussmann, Irma Silva-Zolezzi, Mónica Ancira-Moreno, Carolina Vargas-Martinez, Aristea Binia, Rocío Gonzalez-Alberto, Rafael Bojalil, Felipe Vadillo-Ortega, Isabelle Castan, Adriana Angeles-Quezada, Carlos Pérez-Ortega, Silvia Fernández, M. Elizabeth Tejero, Juan Carlos López-Alvarenga |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Type 2 diabetes Biology Carbohydrate metabolism Biochemistry 03 medical and health sciences chemistry.chemical_compound Fish Oils Gene Frequency Dietary Sucrose Internal medicine Fatty Acids Omega-3 medicine Humans PPAR alpha Mexico Molecular Biology Triglycerides chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Adiponectin Fish oil medicine.disease Lipids Eicosapentaenoic acid PPAR gamma Treatment Outcome Endocrinology chemistry Docosahexaenoic acid Dietary Supplements Body Composition Female Glycated hemoglobin Biomarkers Polyunsaturated fatty acid |
| Zdroj: | The Journal of Nutritional Biochemistry. 43:98-106 |
| ISSN: | 0955-2863 |
| DOI: | 10.1016/j.jnutbio.2017.02.002 |
| Popis: | Polyunsaturated fatty acids (PUFA) contained in fish oil (FO) are ligands for peroxisome proliferator-activated receptors (PPAR) that may induce changes in cardiometabolic markers. Variation in PPAR genes may influence the beneficial responses linked to FO supplementation in young adults. The study aimed to analyze the effect of FO supplementation on glucose metabolism, circulating lipids and inflammation according to PPARα L162V and PPARγ2 P12A genotypes in young Mexican adults. 191 young, non-smoking subjects between 18 and 40 years were included in a one-arm study. Participants were supplemented with 2.7 g/day of EPA+DHA, during six weeks. Dietary analysis, body composition measurements and indicators for glucose metabolism, circulating lipids, and markers for inflammation were analyzed before and after intervention. An overall decrease in triglycerides (TG) and an increase in HS-ω3 index were observed in all subjects [-4.1 mg/dL, (SD:±51.7), P=.02 and 2.6%, (SD:±1.2), P |
| Databáze: | OpenAIRE |
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