Prevalence, risk factors and therapeutic aspects of injuries and accidents in women with epilepsy
| Autor: | Ingo Marzi, Esther Paule, Adam Strzelczyk, Nicolas Söhling, Felix Rosenow, Laurent M. Willems, René D. Verboket, Susanne Knake |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Sports medicine Adolescent Osteoporosis Critical Care and Intensive Care Medicine Lacerations 03 medical and health sciences Epilepsy Fractures Bone Young Adult 0302 clinical medicine Quality of life Risk Factors Germany medicine Prevalence Humans Orthopedics and Sports Medicine Aged 030222 orthopedics Osteomalacia biology business.industry 030208 emergency & critical care medicine Middle Aged medicine.disease Eria biology.organism_classification Accidents Cohort Emergency Medicine Anxiety Wounds and Injuries Surgery Female medicine.symptom business Burns Osteoporotic Fractures |
| Zdroj: | European journal of trauma and emergency surgery : official publication of the European Trauma Society. 45(3) |
| ISSN: | 1863-9941 |
| Popis: | Epilepsy-related injuries and accidents (ERIA) are a frequent cause of hospitalisation and represent a relevant burden for patients with epilepsy. In particular, osteoporosis and other gender-specific aspects may increase the risk of seizure-related fractures and injuries in women with epilepsy. The aim of this analysis is to determine the prevalence and clinical nature of ERIA in a cohort of women with epilepsy, to identify possible determinants including osteoporosis and to give an overview of the current knowledge of clinically important prophylactic and therapeutic aspects. In total, 167 women (mean age 39.0 years, range 18–67 years) with established diagnosis of epilepsy (mean disease duration 18.2 years, range 0–64) were analysed for the occurrence of ERIA. Overall, 22 patients (13.2%) reported at least one ERIA (mean number 3.4, ± 3.1) during the last three months prior to enrollment. The most frequent types of ERIA were lacerations (n = 7/22; 31.8%), abrasions, cuts, bruises or hematoma (n = 6/22, 27.3%), burns (n = 3/22, 13.6%), and fractures (n = 3/22, 13.6%). Moreover, one seizure-related road traffic accident with consecutive trauma (4.5%) was reported. Ictal falls, periictal abnormalities of behaviour and missing seizure freedom were associated with ERIA. Furthermore, female patients with ERIA had a significantly reduced quality of life (QoL, p = 0.002) and increased anxiety (p = 0.008) compared to patients without ERIA. A review of the pertinent literature suggests decreased bone mineral density and use of enzyme-inducing AEDs to be risk factors for ERIA in women with epilepsy. ERIA represent relevant complications for women with epilepsy and are associated with a lower QoL and anxiety compared with non-affected controls. Improvement of anticonvulsive treatment and therapy for osteoporosis or osteomalacia may help to decrease ERIA and the associated burden. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink