Controlling Spatial Heat and Light Distribution by Using Photothermal Enhancing Auto-Regulated Liposomes (PEARLs)
| Autor: | Robert A. Weersink, Gang Zheng, Kenneth K. Ng, Liang Lim, Brian C. Wilson |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Hot Temperature Light Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis Irradiation Absorption (electromagnetic radiation) J-aggregate Liposome business.industry General Chemistry Photothermal therapy Phototherapy 021001 nanoscience & nanotechnology Photochemical Processes 0104 chemical sciences Solutions Wavelength Heat generation Liposomes Optoelectronics Nanoparticles 0210 nano-technology business |
| Zdroj: | Angewandte Chemie (International ed. in English). 55(34) |
| ISSN: | 1521-3773 |
| Popis: | Photothermal therapy (PTT) is enhanced by the use of nanoparticles with a large optical absorption at the treatment wavelength. However, this comes at the cost of higher light attenuation that results in reduced depth of heating as well as larger thermal gradients, leading to potential over- and under-treatment in the target tissue. These limitations can be overcome by using photothermal enhancing auto-regulating liposomes (PEARLs), based on thermochromic J-aggregate forming dye-lipid conjugates that reversibly alter their absorption above a predefined lipid phase-transition temperature. Under irradiation by near-infrared light, deeper layers of the target tissue revert to the intrinsic optical absorption, halting the temperature rise and enabling greater light penetration and heat generation at depth. This effect is demonstrated in both nanoparticle solutions and in gel phantoms containing the nanoparticles. |
| Databáze: | OpenAIRE |
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