Numerical and ex vivo studies of a bioprobe developed for laser-induced thermotherapy (LITT) in contact with liver tissue
Autor: | F. Monchau, Thierry Chartier, J-C. Hornez, Olivier Carpentier, B. Genestie |
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Přispěvatelé: | Axe 1 : procédés céramiques (SPCTS-AXE1), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 (LGCgE), Université d'Artois (UA)-Université de Lille-Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Lille Douai), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Laboratoire des Matériaux Céramiques et Procédés Associés - EA 2443 (LMCPA), Université de Valenciennes et du Hainaut-Cambrésis (UVHC), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM), Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France) |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Optical fiber
Materials science Laser-induced thermotherapy Laser source Biomedical Engineering Biophysics Irradiated Volume Biosensing Techniques 02 engineering and technology Models Biological 030218 nuclear medicine & medical imaging law.invention [SPI.MAT]Engineering Sciences [physics]/Materials 03 medical and health sciences 0302 clinical medicine law Liver tissue Animals Irradiation ComputingMilieux_MISCELLANEOUS Lasers Hyperthermia Induced [CHIM.MATE]Chemical Sciences/Material chemistry 021001 nanoscience & nanotechnology Laser Liver Cattle 0210 nano-technology Ex vivo Biomedical engineering |
Zdroj: | Medical Engineering & Physics Medical Engineering & Physics, 2016, 38 (8), pp.733-740. ⟨10.1016/j.medengphy.2016.04.024⟩ Medical Engineering and Physics Medical Engineering and Physics, Elsevier, 2016, 38 (8), pp.733-740. ⟨10.1016/j.medengphy.2016.04.024⟩ |
ISSN: | 1350-4533 1873-4030 |
DOI: | 10.1016/j.medengphy.2016.04.024⟩ |
Popis: | This work is based on the production of a bioprobe that is compatible with magnetic resonance imaging (MRI) for laser-induced thermotherapy (LITT) in liver cancer laser therapy. This probe is made of an alumina tube (3-mm diameter) in which an optical fibre is centred and fixed. A shooting window (20mm) is created using a mechanical rectifier. The device is then consolidated by the injection of a transparent and heat-resistant resin. Through numerical modelling, the thermal power damping of the laser source is evaluated as well as the propagation of the heat in the ex vivo liver tissue according to different heating scenarios. These analyses allow for an estimation of the irradiated volume. Ex vivo tests were performed on bovine liver to confirm the adequacy of the bioprobe for LITT and of the irradiated volumes predicted by the numerical model. There was a difference of 8% between the simulations and ex vivo experiments. The pulsed mode heating scenario was the most effective under the experimental conditions. |
Databáze: | OpenAIRE |
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