Determination of mean recency period for estimation of HIV type 1 Incidence with the BED-capture EIA in persons infected with diverse subtypes
| Autor: | Bharat Parekh, Debra L. Hanson, J. W. Hargrove, Timothy A. Green, Trudy Dobbs, Niel Constantine, Julie Overbaugh, J. Steven McDougal, Bernard M. Branson |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Time Factors Immunology Population Human immunodeficiency virus (HIV) HIV Infections Biology Mixed effects regression HIV Antibodies medicine.disease_cause Gastroenterology Incidence estimation Cohort Studies Immunoenzyme Techniques Virology Internal medicine HIV Seropositivity medicine Cutoff Humans Seroconversion education education.field_of_study Incidence (epidemiology) AIDS Serodiagnosis Infectious Diseases Immunoglobulin G HIV-1 Cohort study |
| Zdroj: | AIDS research and human retroviruses. 27(3) |
| ISSN: | 1931-8405 |
| Popis: | The IgG capture BED enzyme immunoassay (BED-CEIA) was developed to detect recent HIV-1 infection for the estimation of HIV-1 incidence from cross-sectional specimens. The mean time interval between seroconversion and reaching a specified assay cutoff value [referred to here as the mean recency period (ω)], an important parameter for incidence estimation, is determined for some HIV-1 subtypes, but testing in more cohorts and new statistical methods suggest the need for a revised estimation of ω in different subtypes. A total of 2927 longitudinal specimens from 756 persons with incident HIV infections who had been enrolled in 17 cohort studies was tested by the BED-CEIA. The ω was determined using two statistical approaches: (1) linear mixed effects regression (ω(1)) and (2) a nonparametric survival method (ω(2)). Recency periods varied among individuals and by population. At an OD-n cutoff of 0.8, ω(1) was 176 days (95% CL 164-188 days) whereas ω(2) was 162 days (95% CL 152-172 days) when using a comparable subset of specimens (13 cohorts). When method 2 was applied to all available data (17 cohorts), ω(2) ranged from 127 days (Thai AE) to 236 days (subtypes AG, AD) with an overall ω(2) of 197 days (95% CL 173-220). About 70% of individuals reached a threshold OD-n of 0.8 by 197 days (mean ω) and 95% of people reached 0.8 OD-n by 480 days. The determination of ω with more data and new methodology suggests that ω of the BED-CEIA varies between different subtypes and/or populations. These estimates for ω may affect incidence estimates in various studies. |
| Databáze: | OpenAIRE |
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