Ambulatory Activity Components Deteriorate Differently across Neurodegenerative Diseases: A Cross-Sectional Sensor-Based Study

Autor: Karin Srulijes, Matthis Synofzik, Cornelia Schatton, Jochen Klenk, Clemens Becker, Lars Schwickert, Walter Maetzler
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Parkinson's disease
Ataxia
physiopathology [Supranuclear Palsy
Progressive]
Cross-sectional study
Walking
Disease
Motor Activity
Severity of Illness Index
Progressive supranuclear palsy
physiopathology [Ataxia]
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Severity of illness
medicine
Humans
ddc:610
030212 general & internal medicine
Aged
business.industry
physiopathology [Neurodegenerative Diseases]
Neurodegenerative Diseases
Parkinson Disease
medicine.disease
Cross-Sectional Studies
Neurology
Ambulatory
Disease Progression
Physical therapy
Biomarker (medicine)
Female
physiopathology [Parkinson Disease]
Supranuclear Palsy
Progressive
Neurology (clinical)
medicine.symptom
business
human activities
030217 neurology & neurosurgery
Zdroj: Neurodegenerative diseases 16(5-6), 317-323 (2016). doi:10.1159/000444802
ISSN: 1660-2862
1660-2854
DOI: 10.1159/000444802
Popis: Background and Purpose: Reduced ambulatory activity is a major burden in neurodegenerative disease (NDD), leading to severe restrictions in social participation and further deterioration of motor capacities. However, objective evidence on walking behavior patterns and components underlying this impairment and its decline with disease progression is scarce for many NDDs. We aimed to unravel the detailed metrics underlying the reduced ambulatory activity in selected NDDs, and their relation to disease duration. We hypothesized that progressively reduced ambulatory activity is a feature shared across different NDDs, characterized by changes in both common and distinct components. Methods: Sixty-five subjects with NDD (n = 34 degenerative ataxia; n = 15 progressive supranuclear palsy, and n = 16 Parkinson's disease) and 38 healthy older adults (total n = 103) wore a three-axial accelerometer (activPAL3™) for 7 consecutive days. Detailed metrics of ambulatory activity were calculated. Results: The average daily walking duration was significantly decreased in all three NDDs, yet characterized by a differential pattern of changes in number and length of walking bouts and sit-to-stand transfers. Decline in walking duration progressed with increased disease duration in all three NDDs, yet at a differing rate. This decline was associated with progressive reductions in walking bout length and walking behavior pattern diversity in all three NDDs. Conclusions: These findings provide objective evidence that reduced ambulatory activity is a shared feature across different NDDs. Moreover, they reveal that several underlying walking behavior components change with increasing disease duration, yet at a differing rate in different NDDs. This indicates that metric analysis of ambulatory activity might provide ecologically relevant and disease-specific progression and outcome markers in several NDDs.
Databáze: OpenAIRE
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