Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review

Autor:	Rong Wu, Zeyao Tang, Hailong Li, Yushu Song, Jing Zhang, Qinyan Wang, Eskandar Qaed, Jiang Jiang, Xinmiao Bu
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Cancer Research Programmed cell death Cell Survival Antineoplastic Agents Review Biology lcsh:RC254-282 Metastasis Suppression 03 medical and health sciences chemistry.chemical_compound Preference for cancer stem cells (CSCs) or cancer parasitic diseases Autophagy Animals Humans Autophagy regulator Salinomycin Pyrans lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology Oncology chemistry Anticancer agent Apoptosis Cancer cell Cancer research Neoplastic Stem Cells Signal transduction Stem cell Biomarkers Signal Transduction
Zdroj:	Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-13 (2018) Journal of Experimental & Clinical Cancer Research : CR
ISSN:	1756-9966
DOI:	10.1186/s13046-018-0680-z
Popis:	Since Salinomycin (Sal) emerged its ability to target breast cancer stem cells in 2009, numerous experiments have been carried out to test Sal’s anticancer effects. What deserve to be mentioned is that Sal can efficiently induce proliferation inhibition, cell death and metastasis suppression against human cancers from different origins both in vivo and in vitro without causing serious side effects as the conventional chemotherapeutical drugs on the body. There may be novel cell death pathways involving the anticancer effects of Sal except the conventional pathways, such as autophagic pathway. This review is focused on how autophagy involves the effects of Sal, trying to describe clearly and systematically why autophagy plays a vital role in predominant anticancer effects of Sal, including its distinctive characteristic. Based on recent advances, we present evidence that a dual role of Sal involving in autophagy may account for its unique anticancer effects - the preference for cancer cells. Further researches are required to confirm the authenticity of this suppose in order to develop an ideal anticancer drug.
Databáze:	OpenAIRE
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