Chromosomal Anomalies in Stage D1 Prostate Adenocarcinoma Primary Tumors and Lymph Node Metastases Detected by Fluorescence in Situ Hybridization

Autor:	Michael M. Lieber, Sharon M. D'Souza-Gburek, Robert B. Jenkins, Thomas A. Kollmorgen, Junqi Qian, Bernard M. Gburek
Rok vydání:	1997
Předmět:	Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Urology Aneuploidy medicine.disease Primary tumor Metastasis Prostate cancer medicine.anatomical_structure Prostate Medicine Adenocarcinoma business Lymph node Fluorescence in situ hybridization
Zdroj:	Journal of Urology. 157:223-227
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(01)65331-x
Popis:	Purpose: We determined if characteristic chromosomal anomalies exist within the primary tumors and lymph node metastases in patients with stage D1 prostate cancer, and compared the patterns of chromosomal alterations between primary tumors and nodal metastases.Materials and Methods: Fluorescence in situ hybridization analysis using peri-centromeric probes for chromosomes 6, 7, 8, 17, X and Y was performed on 5 micro. sections from paraffin embedded tissue blocks obtained from 23 consecutive patients who underwent radical prostatectomy and bilateral pelvic lymphadenectomy in 1990 for stage D1 prostate cancer.Results: The dominant focus of primary tumor was compared to matched nodal metastases in 12 cases. Five of 12 primary tumor foci (41.7%) had similar chromosomal gains and the same fluorescence in situ hybridization ploidy result as the corresponding nodal metastases. Chromosomes 7 and X (73.2% of cases) were most frequently gained in the primary tumors, and chromosomes X and Y (81.2% of cases) ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60321509fbe3e6c6e229efd55dccbfa3 https://doi.org/10.1016/s0022-5347(01)65331-x Zobrazit plný text záznamu