False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease
Autor: | Ka Li Kwok, Wilfred Hs Wong, Kwok-Hung Chan, Keith Ts Tung, Joshua Sc Wong, Yuen Yu Lam, Ian C. K. Wong, Godfrey Cf Chan, Xue Li, Celine Sl Chui, Christina Sm Wong, Dennis Chi Yu Au, Kelvin K. W. To, Marco Hk Ho, Kwok-Yung Yuen, Winnie Wy Tso, Gilbert T. Chua, Carol Hy Fong, Patrick Ip, Mike Yw Kwan, Rosa S. Wong |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Antibodies Viral Polymerase Chain Reaction Serology 0302 clinical medicine 030212 general & internal medicine False positive Child Immunoassay Aspirin medicine.diagnostic_test biology General Medicine Nucleocapsid Proteins Infectious Diseases Molecular Diagnostic Techniques Spike Glycoprotein Coronavirus Hong Kong Antibody Coronavirus Infections Systemic vasculitis medicine.drug Microbiology (medical) Pneumonia Viral 030106 microbiology Mucocutaneous Lymph Node Syndrome Article Betacoronavirus 03 medical and health sciences medicine Coronavirus Nucleocapsid Proteins Humans Microneutralization Assay False Positive Reactions Serologic Tests Pandemics Retrospective Studies Chinese Kawasaki disease SARS-CoV-2 business.industry COVID-19 Outbreak Phosphoproteins medicine.disease Antibodies Neutralizing Immunology biology.protein business |
Zdroj: | Diagnostic Microbiology and Infectious Disease |
ISSN: | 0732-8893 |
DOI: | 10.1016/j.diagmicrobio.2020.115141 |
Popis: | Background Kawasaki disease (KD) is an acute febrile and eruptive disease with systemic vasculitis predominantly affecting young East Asian children. Recent reports showed that children with KD-like disease from KD low prevalence regions had positive SARS-CoV-2 serology despite a negative SARS-CoV-2 polymerase chain reaction (PCR) in respiratory samples. Objectives To describe three pediatric Kawasaki Disease patients with false positive SARS-CoV-2 serology. Study design We retrospectively recruited children with KD diagnosed during the COVID-19 outbreak in Hong Kong. Clinical characteristics and laboratory test results including SARS-CoV-2 PCR results were retrieved. We performed a microparticle-based immunoassay for the detection of IgG against nucleoprotein (NP) and spike protein receptor binding domain (RBD), and a microneutralization assay for the detection of neutralizing antibodies. Results Three Chinese children with typical KD were identified. They had no epidemiological links with COVID-19 patients and tested negative for SARS-CoV-2 NPA PCR. They were treated with IVIG and aspirin, and were discharged without complications. Subsequently two of them were tested positive against anti-RBD and anti-NP antibodies and one was tested positive against anti- RBD antibodies. However, microneutralization assay showed that neutralizing antibodies were absent, suggesting a false-positive IgG result. Conclusion Detection of neutralizing antibodies is recommended to confirm previous SARS-CoV-2 infection in IgG-positive but PCR-negative patients. |
Databáze: | OpenAIRE |
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