Validation of dose painting of lung tumours using alanine/EPR dosimetry

Autor: Jan Rødal, Eirik Malinen, Michel Öllers, Jørund Graadal Svestad, B.L. Rekstad, Wouter van Elmpt, Ingerid Skjei Knudtsen, Erlend Peter Skaug Sande, Eli O. Hole
Přispěvatelé: Radiotherapie, RS: FHML non-thematic output, RS: GROW - School for Oncology and Reproduction, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
Rok vydání: 2016
Předmět:
Lung Neoplasms
medicine.medical_treatment
VMAT
Imaging phantom
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
medicine
Humans
Dosimetry
Radiology
Nuclear Medicine and imaging
IMRT
Radiometry
Lung cancer
Radiation treatment planning
radiotherapy
functional imaging
Alanine
Dosimeter
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Radiotherapy Planning
Computer-Assisted
Electron Spin Resonance Spectroscopy
Radiotherapy Dosage
phantom
medicine.disease
Radiation therapy
lung cancer
PET
Positron emission tomography
Positron-Emission Tomography
030220 oncology & carcinogenesis
Radiotherapy
Intensity-Modulated
Radiopharmaceuticals
Lung tumours
Nuclear medicine
business
Radiotherapy
Image-Guided
Zdroj: Physics in Medicine and Biology, 61(6), 2243-2254. IOP Publishing Ltd.
ISSN: 1361-6560
0031-9155
DOI: 10.1088/0031-9155/61/6/2243
Popis: Biologic image guided radiotherapy (RT) with escalated doses to tumour sub volumes challenges today's RT dose planning and delivery systems. In this phantom study, we verify the capability of a clinical dose planning and delivery system to deliver an 18F-FDG-PET based dose painted treatment plan to a lung tumour. Furthermore, we estimate the uncertainties of the dose painted treatment compared to conventional RT plans. An anthropomorphic thorax phantom of polystyrene and polyurethane was constructed based on CT images of a lung cancer patient. 101 EPR/alanine dosimeters were placed in separate cavities within the phantom. IMRT and VMAT plans were generated in Eclipse (version 10.0, Analytical Anisotropic Algorithm version 10.2.28, Varian Medical Systems, Inc.) for 6 and 15 MV photons, based on 18F-FDG-PET/CT images of the patient. A boost dose of 3.8 Gy/fraction was given to the 18F-FDG-avid region (biological planning volume; BTV), whereas 3.1 Gy/fraction was planned to the planning target volume (PTV, excluding the BTV). For the homogenous plans, 3.2 Gy/fraction was given to the PTV. Irradiation of the phantom was carried out at a Varian Trilogy linear accelerator (Varian Medical Systems, Inc.). Uncertainties involved in treatment planning and delivery were estimated from portal dosimetry gamma evaluation. Measured and calculated doses were compared by Bland-Altmann analysis. For all treatment plans, all dose-volume objectives could be achieved in the treatment planning system. The mean absolute differences between calculated and measured doses were small (
Databáze: OpenAIRE
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