Mast Cell: An Emerging Partner in Immune Interaction
| Autor: | Francesca Mion, Luca Danelli, Riccardo Sibilano, Giorgia Gri, Elena Betto, Carlo Pucillo, Federica D’Incà, Barbara Frossi |
|---|---|
| Přispěvatelé: | GRI, Giorgia, FROSSI, Barbara, D'INCA', Federica, DANELLI, Luca, BETTO, Elena, MION, Francesca, Sibilano R, PUCILLO, Carlo Ennio Michele |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
cell–cell interaction Immunology Priming (immunology) Review Article Biology Immuneregulation regulatory cells Immune system Cell–cell interaction adaptive immune cells Cell-cell interaction medicine Immunology and Allergy innate immune cells innate immunity Mast cell Innate immune system Effector Peripheral tolerance adaptive immunity Acquired immune system Cell biology medicine.anatomical_structure lcsh:RC581-607 mast cell |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 3 (2012) |
| ISSN: | 1664-3224 |
| Popis: | Mast cells (MCs) are currently recognized as effector cells in many settings of the immune response, including host defense, immune regulation, allergy, chronic inflammation, and autoimmune diseases. MC pleiotropic functions reflect their ability to secrete a wide spectrum of preformed or newly synthesized biologically active products with pro-inflammatory, anti-inflammatory and/or immunosuppressive properties, in response to multiple signals. Moreover, the modulation of MC effector phenotypes relies on the interaction of a wide variety of membrane molecules involved in cell–cell or cell-extracellular-matrix interaction. The delivery of co-stimulatory signals allows MC to specifically communicate with immune cells belonging to both innate and acquired immunity, as well as with non-immune tissue-specific cell types. This article reviews and discusses the evidence that MC membrane-expressed molecules play a central role in regulating MC priming and activation and in the modulation of innate and adaptive immune response not only against host injury, but also in peripheral tolerance and tumor-surveillance or -escape. The complex expression of MC surface molecules may be regarded as a measure of connectivity, with altered patterns of cell–cell interaction representing functionally distinct MC states. We will focalize our attention on roles and functions of recently discovered molecules involved in the cross-talk of MCs with other immune partners. |
| Databáze: | OpenAIRE |
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