First occurrence of Rift Valley fever outbreak in Niger, 2016
| Autor: | Mariama Abdoulaye, Sani Ousmane, Amadou Bailo Diallo, Halima Boubacar Maïnassara, Alkassoum Ibrahim, Fati Sidikou, Abdou Alhassane, Gamou Fall, Baruani Bienvenue, Ali Elh Mahaman, Bassira Issaka, Harouna Djingarey Mamoudou, Jean Testa, Adamou Lagare, Goumbi Kadadé, Ousmane Faye, Bacary D. Sadio, Maman Zaneidou |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Veterinary medicine Time Factors RT‐PCR Adolescent 030231 tropical medicine Biology Virus Serology Disease Outbreaks 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Zoonoses medicine Animals Humans 030212 general & internal medicine Niger Rift Valley fever Child lcsh:Veterinary medicine General Veterinary Animal health outbreak Public health Zoonosis Outbreak Infant Original Articles sequencing Serum samples medicine.disease Rift Valley fever virus Child Preschool lcsh:SF600-1100 Female Original Article ELISA |
| Zdroj: | Veterinary Medicine and Science, Vol 5, Iss 1, Pp 70-78 (2019) Veterinary Medicine and Science |
| ISSN: | 2053-1095 |
| Popis: | Rift Valley fever (RVF) is a mosquito‐borne viral zoonosis causing abortions and high mortality among animals, whereas in humans, the disease is usually mild or asymptomatic. In September 2016, the Republic of Niger declared the first RVF outbreak in the northern region of Tahoua near the Malian border. This study describes the outbreak and reports the results of serological and molecular investigations of the human and animal samples collected. Serum samples from both human and animal suspected cases have been confirmed at the Centre de Recherche Médicale et Sanitaire (CERMES) and the Laboratoire Centrale d'Elevage (LABOCEL) public health and animal reference laboratories, respectively. Techniques for biological confirmation were real time reverse transcription polymerase chain reaction (RT‐PCR) and enzyme linked immunosorbent assay (ELISA). Phylogenetic trees were established after genetic sequencing of the small and medium segments of the RVF virus (RVFV) genome. Out of the 399 human samples collected, 17 (4.3%) were confirmed positive for RVFV. Overall, 33 (8.3%) deaths occurred out of which five (29%) were among the 17 confirmed cases. Regarding animals, 45 samples were tested, three of which were RT‐PCR positive and 24 were IgG positive. The phylogenetic analyses showed that the Niger strains clustered with Senegal 2013 and Mauritania 2015 RVFV strains. This first outbreak of RVF was very challenging for public and animal health laboratories in Niger. Besides resulting in human deaths, important loss of cattle has been reported. Therefore, vigilance has to be strengthened emphasising vector control strategies and active surveillance among animals. |
| Databáze: | OpenAIRE |
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