Stimulation by ATP of protein initiation in a prokaryotic organism, B. stearothermophilus
Autor: | M. Graffe, Marianne Grunberg-Manago, Alan C. Kay |
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Jazyk: | angličtina |
Předmět: |
Time Factors
GTP' Guanine Biophysics Stimulation Biochemistry Ribosome Geobacillus stearothermophilus chemistry.chemical_compound Adenosine Triphosphate RNA Transfer Species Specificity Peptide Initiation Factors Structural Biology Escherichia coli Genetics Nucleotide Peptide Chain Initiation Translational Molecular Biology chemistry.chemical_classification Binding Sites Chemistry Prokaryotic initiation factor-2 Cell Biology Phosphate Molecular biology Guanine Nucleotides Stimulation Chemical RNA Bacterial bacteria Phosphorylation Puromycin Guanosine Triphosphate Ribosomes |
Zdroj: | FEBS Letters. (1-2):112-118 |
ISSN: | 0014-5793 |
DOI: | 10.1016/0014-5793(75)80237-7 |
Popis: | In contrast to E. coli ribosomes, with B. stearothermophilus ribosomes initiation complex formation is stimulated by ATP as well as GTP, but maximum stimulation occurs when both the nucleotides are present; and their terminal phosphate must be hydrolysable. In the presence of ATP and GTP, B. stearothermophilus ribosomes synthesize a highly phosphorylated guanine derivative, ppGpp, and the role of ATP in initiation might be related to this synthesis. We discarded the role of ATP as being trivial and corresponding solely to the well-known effect on eukaryotic systems. |
Databáze: | OpenAIRE |
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