Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum
| Autor: | Lu Chen, Zhizhen Zhang, Xiao-Yuan Lian, Weiyun Chai |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cell cycle checkpoint Mice Nude Pharmaceutical Science Apoptosis Asteraceae Analytical Chemistry Inhibitory Concentration 50 Mice 03 medical and health sciences 0302 clinical medicine In vivo Glioma Drug Discovery medicine Animals neoplasms Transcription factor Pharmacology Mice Inbred BALB C Tripolium pannonicum biology Chemistry Organic Chemistry Cell Cycle Checkpoints Cell cycle biology.organism_classification medicine.disease Antineoplastic Agents Phytogenic nervous system diseases 030104 developmental biology Complementary and alternative medicine Mechanism of action 030220 oncology & carcinogenesis Cancer research Molecular Medicine medicine.symptom Apoptosis Regulatory Proteins |
| Zdroj: | Planta Medica. 84:786-794 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0044-101038 |
| Popis: | Tripolinolate A as a new bioactive phenolic ester was previously isolated from a halophyte of Tripolium pannonicum. However, the in vitro and in vivo anti-glioma effects and mechanism of tripolinolate A have not been investigated. This study has demonstrated that (1) tripolinolate A inhibited the proliferation of different glioma cells with IC50 values of 7.97 to 14.02 µM and had a significant inhibitory effect on the glioma growth in U87MG xenograft nude mice, (2) tripolinolate A induced apoptosis in glioma cells by downregulating the expressions of antiapoptotic proteins and arrested glioma cell cycle at the G2/M phase by reducing the expression levels of cell cycle regulators, and (3) tripolinolate A also remarkably reduced the expression levels of several glioma metabolic enzymes and transcription factors. All data together suggested that tripolinolate A had significant in vitro and in vivo anti-glioma effects and the regulation of multiple tumor-related regulators and transcription factors might be responsible for the activities of tripolinolate A against glioma. |
| Databáze: | OpenAIRE |
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