Incidental colonic focal FDG uptake on PET/CT: can the maximum standardized uptake value (SUVmax) guide us in the timing of colonoscopy?
| Autor: | R. G. M. Keijsers, B. C. A. J. Loffeld, G. Dun, F. B. van Hoeij, B. L. A. M. Weusten, P. H. G. M. Stadhouders |
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| Přispěvatelé: | Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, Gastroenterology and Hepatology, Other departments |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Colon Adenoma Colonoscopy Standardized uptake value Multimodal Imaging Diagnosis Differential Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging In patient Aged PET-CT Incidental Findings medicine.diagnostic_test business.industry Incidentaloma Fdg uptake General Medicine Middle Aged Positron emission tomography Positron-Emission Tomography Colonic Neoplasms Female Radiology Radiopharmaceuticals business Tomography X-Ray Computed |
| Zdroj: | European journal of nuclear medicine and molecular imaging, 42(1), 66-71. Springer Verlag |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | In patients undergoing F-18-FDG PET/CT, incidental colonic focal lesions can be indicative of inflammatory, premalignant or malignant lesions. The maximum standardized uptake value (SUVmax) of these lesions, representing the FDG uptake intensity, might be helpful in differentiating malignant from benign lesions, and thereby be helpful in determining the urgency of colonoscopy. The aim of our study was to assess the incidence and underlying pathology of incidental PET-positive colonic lesions in a large cohort of patients, and to determine the usefulness of the SUVmax in differentiating benign from malignant pathology. The electronic records of all patients who underwent FDG PET/CT from January 2010 to March 2013 in our hospital were retrospectively reviewed. The main indications for PET/CT were: characterization of an indeterminate mass on radiological imaging, suspicion or staging of malignancy, and suspicion of inflammation. In patients with incidental focal FDG uptake in the large bowel, data regarding subsequent colonoscopy were retrieved, if performed within 120 days. The final diagnosis was defined using colonoscopy findings, combined with additional histopathological assessment of the lesion, if applicable. Of 7,318 patients analysed, 359 (5 %) had 404 foci of unexpected colonic FDG uptake. In 242 of these 404 lesions (60 %), colonoscopy follow-up data were available. Final diagnoses were: adenocarcinoma in 25 (10 %), adenoma in 90 (37 %), and benign in 127 (53 %). The median [IQR] SUVmax was significantly higher in adenocarcinoma (16.6 [12 - 20.8]) than in benign lesions (8.2 [5.9 - 10.1]; p |
| Databáze: | OpenAIRE |
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