Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe
| Autor: | Tao Jiang, Weihang Ji, Dongyuan Zhao, Deliang Fu, Yonghui Deng, Juntao Dai, Yu Zhang, Ahmed A. Elzatahry, Daoying Geng, Yongjian Jiang, Hang He, Shaojun Liu, Abdulaziz Ali Alghamdi, Hengchao Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Biophysics Contrast Media Molecular Probe Techniques Nanoparticle Bioengineering Nanotechnology Nanoconjugates 02 engineering and technology 010402 general chemistry Multimodal Imaging Peptides Cyclic Sensitivity and Specificity 01 natural sciences Nanomaterials Biomaterials Mice Nanocapsules Cell Line Tumor Pancreatic cancer medicine Animals Magnetite Nanoparticles Mice Inbred BALB C Reproducibility of Results Mesoporous silica 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Pancreatic Neoplasms Mechanics of Materials Molecular Probes Cancer cell Ceramics and Composites Female Molecular imaging 0210 nano-technology Mesoporous material Porosity Nanospheres Conjugate |
| Zdroj: | Biomaterials. 115:9-18 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2016.11.006 |
| Popis: | Immobilization of a ligand that selectively interacts with cancer cells to nanomaterials can enhance their diagnostic and therapeutic efficiency. In this study, we firstly demonstrate the high expression of receptor for cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) in both mouse and human pancreatic cancer. Based on these findings, sub-50 nm multifunctional superparamagnetic mesoporous nanospheres with surface modified with LyP-1 are rationally designed. Theses nanospheres have a core of silica-protected magnetite nanoparticle and a shell of FITC-labeled mesoporous silica, and they are able to specifically recognize and conjugate with the pancreatic cancer cell in vitro, as verified by the combined techniques of fluorescent imaging and T2 weight magnetic resonance imaging. After systematic administration, these LyP-1 immobilized nanospheres are found to actively target to mouse orthotopic xenograft of pancreatic cancer, which opens up the door for applications in early probing and diagnosis of pancreatic cancer by the multimodal imaging. |
| Databáze: | OpenAIRE |
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