Pre- and postoperative sequential study on the serum gastrin level in patients with lung cancer
| Autor: | Zhu Wu, Huaibin Zhang, Junjie Yang, Zipu Tain, Qinghua Zhou, Xiaojie Pang, Zhenhua Yang |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Lung Neoplasms Adenocarcinoma Gastroenterology Thoracic Diseases Internal medicine Gastrin-releasing peptide Gastrins medicine Humans Postoperative Period Carcinoma Small Cell Lung cancer Aged Neoplasm Staging Gastrin Lung business.industry Respiratory disease Cancer General Medicine Middle Aged Prognosis medicine.disease Primary tumor medicine.anatomical_structure Gastrin-Releasing Peptide Oncology Lymphatic Metastasis Carcinoma Squamous Cell Female Surgery Peptides business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Surgical Oncology. 51:22-25 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.2930510108 |
| Popis: | Serial changes in serum gastrin level were detected by radioimmunoassay in 58 lung cancer patients before and after operation. In comparing these tests with those of 40 cases of noncancerous thoracic lesions and 151 normal adults, the serum gastrin from lung cancer patients is significantly higher than that of noncancerous thoracic lesions and normal individuals (P less than 0.01). The gastrin level is closely related to stage of cancer, size of primary tumor, presence of lymph node metastasis, and type of histological classification. The serum gastrin was found to decrease gradually after the removal of the tumor and to return to normal on the 14th postoperative day. Those patients whose serum gastrin level can return to normal on the 14th postoperative day will have a good prognosis; if not, their prognosis will be very poor. These results suggest that serum from patients with lung cancer contains a high concentration of gastrin that can help differentiate benign from malignant thoracic lesions and evaluate prognosis of patients with lung cancer. Therefore, the cause of high serum gastrin in patients with lung cancer is likely due to the gastrin-producing property of the lung cancer cells. |
| Databáze: | OpenAIRE |
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