Human-Derived Model Systems in Gynecological Cancer Research
| Autor: | Kadi Lõhmussaar, Hans Clevers, Matteo G Boretto |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Genital Neoplasms Female Reproductive tract Primary Cell Culture Uterus Bioinformatics Vulva Genetic Heterogeneity 03 medical and health sciences 0302 clinical medicine Cell Line Tumor medicine Humans Precision Medicine Personalized therapy Cervix urogenital system business.industry Reproducibility of Results Vulvar cancer medicine.disease Xenograft Model Antitumor Assays Gynecological cancer female genital diseases and pregnancy complications Organoids 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Vagina Female business |
| Zdroj: | Trends in Cancer. 6:1031-1043 |
| ISSN: | 2405-8033 |
| Popis: | The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics and functions. This versatility, in turn, allows for the development of a wide range of epithelial gynecological cancers with distinct features. Thus, reliable model systems are required to better understand the diverse mechanisms involved in the regional pathogenesis of the reproductive tract and improve treatment strategies. Here, we review the current human-derived model systems available to study the multitude of gynecological cancers, including ovarian, endometrial, cervical, vaginal, and vulvar cancer, and the recent advances in the push towards personalized therapy. |
| Databáze: | OpenAIRE |
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