What Is the Role of the New Index Relative Fat Mass (RFM) in the Assessment of Nonalcoholic Fatty Liver Disease (NAFLD)?
Autor: | S. Policarpo, Jorge Luiz Albuquerque Coutinho, Armando Carvalho, Isabel Medeiros, Francisco Velasco, Ana Catarina Alves, Mafalda Bourbon, Mariana V. Machado, Helena Cortez-Pinto, Sofia Carvalhana, Jorge Leitão, Ana P. Silva |
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Rok vydání: | 2019 |
Předmět: |
Male
Endocrinology Diabetes and Metabolism Severity of Illness Index Gastroenterology Body fat percentage Body Mass Index Cohort Studies Liver disease 0302 clinical medicine Non-alcoholic Fatty Liver Disease Nonalcoholic fatty liver disease Health Status Indicators Medicine Prospective Studies Adiposity Ultrasonography Aged 80 and over Nutrition and Dietetics Middle Aged Obesity Morbid Relative Fat Mass Cohort Body Composition Female 030211 gastroenterology & hepatology Waist Circumference Adult medicine.medical_specialty Nonalcoholic Fatty Liver Disease Adolescent 030209 endocrinology & metabolism Diagnostic Techniques Endocrine Young Adult 03 medical and health sciences Predictive Value of Tests Internal medicine Humans Obesity Aged Portugal Adiponectin business.industry nutritional and metabolic diseases medicine.disease Surgery Insulin Resistance Steatohepatitis business Body mass index Dyslipidemia |
Zdroj: | Obesity Surgery. 30:560-568 |
ISSN: | 1708-0428 0960-8923 |
Popis: | Introduction: Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of adiposopathy. Recently, a new score was developed to estimate body fat percentage (relative fat mass, RFM). We aimed to evaluate the value of RFM in predicting the presence and severity of NAFLD, compared with other anthropometric measurements. Methods: RFM, body mass index (BMI), and other anthropometric measurements were evaluated in two cohorts of subjects: a cohort from a Portuguese prospective epidemiological study (e_Cor) and morbidly obese patients with biopsy-proven NAFLD. We evaluated if RFM and BMI were related with the presence and severity of liver disease, which was assessed by noninvasive tools in the first cohort and by liver histology in the morbidly obese cohort. The independence of relations found in univariate analysis was assessed with multivariable logistic regression analysis. Results: In the general population cohort, 744 subjects (48% male) were enrolled. BMI-defined obesity was present in 23% and RFM-defined obesity in 86%. Insulin resistance (IR) related with BMI-defined obesity (OR 4.37 [2.16-8.84]) and weight (OR 1.05 [1.02-1.08]) in men, and waist circumference (WC) (OR 1.07 [1.03-1.11]) in women. Dyslipidemia and hypertension related with RFM-defined obesity in men (OR 2.96 [1.36-6.47] and OR 5.37 [1.31-22.06], respectively). Ultrasound-diagnosed NAFLD in 33% related with weight in men (OR 1.03 [1.003-1.06] and WC in women (OR 1.06 [1.02-1.10]). In men, ALT elevation related with weight (OR 1.04 [1.02-1.07]). In women, advanced fibrosis (estimated by NAFLD Fibrosis Score) associated with BMI-defined obesity (OR 42.43 [3.61-498.13]). In the morbidly obese cohort, 152 subjects were enrolled, of whom 84% were female, 37% had steatohepatitis, and 9.4% had advanced fibrosis. Adiponectin associated inversely and leptin positively with RFM in men. The severity of steatosis increased linearly with BMI and WC in women. Higher BMI associated with steatohepatitis in women and advanced fibrosis in men. Conclusion: RFM-defined obesity better predicted dyslipidemia and hypertension (though not IR) and adipokine imbalance; however, it did not add value to BMI-defined obesity in predicting NAFLD or liver injury. info:eu-repo/semantics/publishedVersion |
Databáze: | OpenAIRE |
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