What Is the Role of the New Index Relative Fat Mass (RFM) in the Assessment of Nonalcoholic Fatty Liver Disease (NAFLD)?

Autor: S. Policarpo, Jorge Luiz Albuquerque Coutinho, Armando Carvalho, Isabel Medeiros, Francisco Velasco, Ana Catarina Alves, Mafalda Bourbon, Mariana V. Machado, Helena Cortez-Pinto, Sofia Carvalhana, Jorge Leitão, Ana P. Silva
Rok vydání: 2019
Předmět:
Male
Endocrinology
Diabetes and Metabolism
Severity of Illness Index
Gastroenterology
Body fat percentage
Body Mass Index
Cohort Studies
Liver disease
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease
Health Status Indicators
Medicine
Prospective Studies
Adiposity
Ultrasonography
Aged
80 and over
Nutrition and Dietetics
Middle Aged
Obesity
Morbid
Relative Fat Mass
Cohort
Body Composition
Female
030211 gastroenterology & hepatology
Waist Circumference
Adult
medicine.medical_specialty
Nonalcoholic Fatty Liver Disease
Adolescent
030209 endocrinology & metabolism
Diagnostic Techniques
Endocrine
Young Adult
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Humans
Obesity
Aged
Portugal
Adiponectin
business.industry
nutritional and metabolic diseases
medicine.disease
Surgery
Insulin Resistance
Steatohepatitis
business
Body mass index
Dyslipidemia
Zdroj: Obesity Surgery. 30:560-568
ISSN: 1708-0428
0960-8923
Popis: Introduction: Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of adiposopathy. Recently, a new score was developed to estimate body fat percentage (relative fat mass, RFM). We aimed to evaluate the value of RFM in predicting the presence and severity of NAFLD, compared with other anthropometric measurements. Methods: RFM, body mass index (BMI), and other anthropometric measurements were evaluated in two cohorts of subjects: a cohort from a Portuguese prospective epidemiological study (e_Cor) and morbidly obese patients with biopsy-proven NAFLD. We evaluated if RFM and BMI were related with the presence and severity of liver disease, which was assessed by noninvasive tools in the first cohort and by liver histology in the morbidly obese cohort. The independence of relations found in univariate analysis was assessed with multivariable logistic regression analysis. Results: In the general population cohort, 744 subjects (48% male) were enrolled. BMI-defined obesity was present in 23% and RFM-defined obesity in 86%. Insulin resistance (IR) related with BMI-defined obesity (OR 4.37 [2.16-8.84]) and weight (OR 1.05 [1.02-1.08]) in men, and waist circumference (WC) (OR 1.07 [1.03-1.11]) in women. Dyslipidemia and hypertension related with RFM-defined obesity in men (OR 2.96 [1.36-6.47] and OR 5.37 [1.31-22.06], respectively). Ultrasound-diagnosed NAFLD in 33% related with weight in men (OR 1.03 [1.003-1.06] and WC in women (OR 1.06 [1.02-1.10]). In men, ALT elevation related with weight (OR 1.04 [1.02-1.07]). In women, advanced fibrosis (estimated by NAFLD Fibrosis Score) associated with BMI-defined obesity (OR 42.43 [3.61-498.13]). In the morbidly obese cohort, 152 subjects were enrolled, of whom 84% were female, 37% had steatohepatitis, and 9.4% had advanced fibrosis. Adiponectin associated inversely and leptin positively with RFM in men. The severity of steatosis increased linearly with BMI and WC in women. Higher BMI associated with steatohepatitis in women and advanced fibrosis in men. Conclusion: RFM-defined obesity better predicted dyslipidemia and hypertension (though not IR) and adipokine imbalance; however, it did not add value to BMI-defined obesity in predicting NAFLD or liver injury. info:eu-repo/semantics/publishedVersion
Databáze: OpenAIRE
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