18F-DG PET/CT in detection of recurrence and metastasis of colorectal cancer
| Autor: | Long-Bang Chen, Hai-Zhu Song, Hong Zhu, Yu-Cai Wang, Jin-Long Tong |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Metastasis Elevated serum Fluorodeoxyglucose F18 Humans Medicine Ct diagnosis Neoplasm Metastasis Aged Retrospective Studies PET-CT business.industry Gastroenterology General Medicine Middle Aged medicine.disease Occult digestive system diseases Carcinoembryonic Antigen Positron-Emission Tomography Female Radiology Neoplasm Recurrence Local Radiopharmaceuticals Ultrasonography Colorectal Neoplasms Tomography X-Ray Computed business Nuclear medicine Semi quantitative Rapid Communication |
| Zdroj: | World Journal of Gastroenterology. 13:5025 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v13.i37.5025 |
| Popis: | AIM: To evaluate the value of 18F-DG PET/CT in detecting recurrence and/or metastasis of colorectal cancer (CRC). METHODS: Combined visual analysis with semiquantitative analysis, the 18F-DG PET/CT whole-body imaging results and the corresponding clinical data of 68 postoperative CRC patients including 48 male and 20 female with average age of 58.1 were analyzed retrospectively. RESULTS: Recurrence and/or metastasis were confirmed in 56 patients in the clinical follow-up after the PET/CT imaging. The sensitivity of PET/CT diagnosis of CRC recurrence and/or metastasis was 94.6%, and the specificity was 83.3%. The positive predictive value (PPV) was 96.4% and the negative predictive value (NPV) was 76.9%. PET/CT imaging detected one or more occult malignant lesions in 8 cases where abdominal/pelvic CT and/or ultrasonography showed negative findings, and also detected more lesions than CT or ultrasonography did in 30.4% (17/56) cases. Recurrence and/or metastasis was detected in 91.7% (22/24) cases with elevated serum CEA levels by 18F-DG PET/CT imaging. CONCLUSION: 18F-DG PET/CT could detect the recurrence and/or metastasis of CRC with high sensitivity and specificity. |
| Databáze: | OpenAIRE |
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