Antimicrobial susceptibility profiles of gram-negative bacteria causing infections collected across India during 2014–2016: Study for monitoring antimicrobial resistance trend report
Autor: | John Antony Jude Prakasah, Camilla Rodrigues, Agila Kumari Pragasam, Rani Diana Sahni, Yamuna Devi Bakthavatchalam, D.S. Chitnis, Indranil Roy, Shalini Anandan, T.N. Dhole, Rajesh Joseph Selvakumar, Bhaskar Narayan Chaudhuri, S Joshi, Balaji Veeraraghavan, Mark Ranjan Jesudason |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Microbiology (medical) Carbapenem 030106 microbiology Immunology lcsh:QR1-502 Penicillanic Acid India Microbial Sensitivity Tests Microbiology Tazobactam beta-Lactamases susceptibility lcsh:Microbiology carbapenem 03 medical and health sciences Antibiotic resistance Immunology and Microbiology (miscellaneous) Drug Resistance Multiple Bacterial Escherichia coli Humans Immunology and Allergy Medicine Pseudomonas Infections colistin Amikacin Respiratory Tract Infections Escherichia coli Infections Piperacillin General Immunology and Microbiology SMART business.industry Antimicrobials Antimicrobial Anti-Bacterial Agents Klebsiella Infections Klebsiella pneumoniae Piperacillin Tazobactam Drug Combination Infectious Diseases Carbapenems Pseudomonas aeruginosa Urinary Tract Infections Colistin business Empiric therapy medicine.drug |
Zdroj: | Indian Journal of Medical Microbiology, Vol 36, Iss 1, Pp 32-36 (2018) |
ISSN: | 1998-3646 0255-0857 |
Popis: | Background: The emergence of antibiotic resistance among bacterial pathogens in the hospital and community has increased the concern to the health-care providers due to the limited treatment options. Surveillance of antimicrobial resistance (AMR) in frequently isolated bacterial pathogens causing severe infections is of great importance. The data generated will be useful for the clinicians to decide empiric therapy on the local epidemiological resistance profile of the antimicrobial agents. This study aims to monitor the distribution of bacterial pathogen and their susceptibility pattern to the commonly used antimicrobial agents. Materials and Methods: This study includes Gram-negative bacilli collected from intra-abdominal, urinary tract and respiratory tract infections during 2014–2016. Isolates were collected from seven hospitals across India. All the study isolates were characterised up to species level, and minimum inhibitory concentration was determined for a wide range of antimicrobials included in the study panel. The test results were interpreted as per standard Clinical Laboratory Standards Institute guidelines. Results: A total of 2731 isolates of gram-negative bacteria were tested during study period. The most frequently isolated pathogens were 44% of Escherichia coli (n = 1205) followed by 25% of Klebsiella pneumoniae (n = 676) and 11% of Pseudomonas aeruginosa (n = 308). Among the antimicrobials tested, carbapenems were the most active, followed by amikacin and piperacillin/tazobactam. The rate of extended-spectrum beta-lactamase (ESBL)-positive isolates were ranged from 66%–77% in E. coli to 61%–72% in K. pneumoniae, respectively. Overall, colistin retains its activity in > 90% of the isolates tested and appear promising. Conclusion: Increasing rates of ESBL producers have been noted, which is alarming. Further, carbapenem resistance was also gradually increasing, which needs much attention. Overall, this study data show that carbapenems, amikacin and colistin continue to be the best agents available to treat drug-resistant infections. Thus continuous monitoring of susceptibility profile of the clinically important Gram-negative pathogens is of great importance to guide effective antimicrobial therapy. |
Databáze: | OpenAIRE |
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