Antimicrobial susceptibility profiles of gram-negative bacteria causing infections collected across India during 2014–2016: Study for monitoring antimicrobial resistance trend report

Autor: John Antony Jude Prakasah, Camilla Rodrigues, Agila Kumari Pragasam, Rani Diana Sahni, Yamuna Devi Bakthavatchalam, D.S. Chitnis, Indranil Roy, Shalini Anandan, T.N. Dhole, Rajesh Joseph Selvakumar, Bhaskar Narayan Chaudhuri, S Joshi, Balaji Veeraraghavan, Mark Ranjan Jesudason
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Microbiology (medical)
Carbapenem
030106 microbiology
Immunology
lcsh:QR1-502
Penicillanic Acid
India
Microbial Sensitivity Tests
Microbiology
Tazobactam
beta-Lactamases
susceptibility
lcsh:Microbiology
carbapenem
03 medical and health sciences
Antibiotic resistance
Immunology and Microbiology (miscellaneous)
Drug Resistance
Multiple
Bacterial
Escherichia coli
Humans
Immunology and Allergy
Medicine
Pseudomonas Infections
colistin
Amikacin
Respiratory Tract Infections
Escherichia coli Infections
Piperacillin
General Immunology and Microbiology
SMART
business.industry
Antimicrobials
Antimicrobial
Anti-Bacterial Agents
Klebsiella Infections
Klebsiella pneumoniae
Piperacillin
Tazobactam Drug Combination
Infectious Diseases
Carbapenems
Pseudomonas aeruginosa
Urinary Tract Infections
Colistin
business
Empiric therapy
medicine.drug
Zdroj: Indian Journal of Medical Microbiology, Vol 36, Iss 1, Pp 32-36 (2018)
ISSN: 1998-3646
0255-0857
Popis: Background: The emergence of antibiotic resistance among bacterial pathogens in the hospital and community has increased the concern to the health-care providers due to the limited treatment options. Surveillance of antimicrobial resistance (AMR) in frequently isolated bacterial pathogens causing severe infections is of great importance. The data generated will be useful for the clinicians to decide empiric therapy on the local epidemiological resistance profile of the antimicrobial agents. This study aims to monitor the distribution of bacterial pathogen and their susceptibility pattern to the commonly used antimicrobial agents. Materials and Methods: This study includes Gram-negative bacilli collected from intra-abdominal, urinary tract and respiratory tract infections during 2014–2016. Isolates were collected from seven hospitals across India. All the study isolates were characterised up to species level, and minimum inhibitory concentration was determined for a wide range of antimicrobials included in the study panel. The test results were interpreted as per standard Clinical Laboratory Standards Institute guidelines. Results: A total of 2731 isolates of gram-negative bacteria were tested during study period. The most frequently isolated pathogens were 44% of Escherichia coli (n = 1205) followed by 25% of Klebsiella pneumoniae (n = 676) and 11% of Pseudomonas aeruginosa (n = 308). Among the antimicrobials tested, carbapenems were the most active, followed by amikacin and piperacillin/tazobactam. The rate of extended-spectrum beta-lactamase (ESBL)-positive isolates were ranged from 66%–77% in E. coli to 61%–72% in K. pneumoniae, respectively. Overall, colistin retains its activity in > 90% of the isolates tested and appear promising. Conclusion: Increasing rates of ESBL producers have been noted, which is alarming. Further, carbapenem resistance was also gradually increasing, which needs much attention. Overall, this study data show that carbapenems, amikacin and colistin continue to be the best agents available to treat drug-resistant infections. Thus continuous monitoring of susceptibility profile of the clinically important Gram-negative pathogens is of great importance to guide effective antimicrobial therapy.
Databáze: OpenAIRE
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