Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction
| Autor: | Alexander E. P. Heazell, Isabel Lorne, Sylvia Lui, Karen Forbes, Bernadette Baker, Rebecca Jones |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Serum Physiology Offspring Placenta Biology Placental dysfunction Gender Studies Sexual dimorphism Endocrinology Human placental lactogen Sex Factors Pregnancy medicine QP1-981 Humans Circulating MicroRNA miRNA Fetus Fetal Growth Retardation Research Pregnancy Outcome Biomarker Stillbirth medicine.disease FGR medicine.anatomical_structure In utero Medicine Gestation Biomarker (medicine) Female |
| Zdroj: | Biology of Sex Differences Biology of Sex Differences, Vol 12, Iss 1, Pp 1-20 (2021) |
| ISSN: | 2042-6410 |
| Popis: | Background Current methods fail to accurately predict women at greatest risk of developing fetal growth restriction (FGR) or related adverse outcomes, including stillbirth. Sexual dimorphism in these adverse pregnancy outcomes is well documented as are sex-specific differences in gene and protein expression in the placenta. Circulating maternal serum microRNAs (miRNAs) offer potential as biomarkers that may also be informative of underlying pathology. We hypothesised that FGR would be associated with an altered miRNA profile and would differ depending on fetal sex. Methods miRNA expression profiles were assessed in maternal serum (> 36 weeks’ gestation) from women delivering a severely FGR infant (defined as an individualised birthweight centile (IBC) Highlights Detection and treatment of pregnancies at high risk of fetal growth restriction (FGR) and stillbirth remains a major obstetric challenge; circulating maternal serum microRNAs (miRNAs) offer potential as novel biomarkers.Unbiased analysis of serum miRNAs in women in late pregnancy identified a specific profile of circulating miRNAs in women with a growth-restricted infant.Some altered miRNAs (miR-28-5p, miR-301a-3p) showed sexually dimorphic expression in FGR pregnancies and others a fetal-sex dependent association to a hormonal marker of placental dysfunction (miR-454-3p, miR-29c-3p).miR-301a-3p and miR-28-5p could potentially be used to predict FGR specifically in pregnancies with a male or female baby, respectively, however larger cohort studies are required.Further investigations of these miRNAs and their relationship to placental dysfunction will lead to a better understanding of the pathophysiology of FGR and why there is differing susceptibility of male and female fetuses to FGR and stillbirth. Supplementary Information The online version contains supplementary material available at 10.1186/s13293-021-00405-z. |
| Databáze: | OpenAIRE |
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