Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension

Autor: Ariadne Malamitsi-Puchner, Aimilia Eirini Papathanasiou, Helen Christou, Despina D. Briana, Christos S. Mantzoros, Fotios Spyropoulos, Kyoung Eun Joung, Zoe Michael
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Glucose uptake
Adipose tissue
030204 cardiovascular system & hematology
lcsh:Chemistry
Rats
Sprague-Dawley
0302 clinical medicine
pulmonary hypertension
Glycolysis
lcsh:QH301-705.5
Beta oxidation
Spectroscopy
Pulmonary Arterial Hypertension
Chemistry
General Medicine
Middle Aged
Computer Science Applications
adipose tissue
Female
Adiponectin
Adult
medicine.medical_specialty
Hypertension
Pulmonary
Adipokine
Fatty Acid-Binding Proteins
Catalysis
Fatty acid-binding protein
Article
Inorganic Chemistry
03 medical and health sciences
Young Adult
Adipokines
Internal medicine
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
Organic Chemistry
Hemodynamics
meta-inflammation
medicine.disease
Pulmonary hypertension
Rats
Fibroblast Growth Factors
PPAR gamma
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
Case-Control Studies
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 1435, p 1435 (2021)
Volume 22
Issue 3
ISSN: 1422-0067
Popis: Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue-derived metabolic regulators are altered in human and experimental PH. We measured circulating levels of fatty acid binding protein 4 (FABP-4), fibroblast growth factor -21 (FGF-21), adiponectin, and the mRNA levels of FABP-4, FGF-21, and peroxisome proliferator-activated receptor γ (PPARγ) in lung tissue of patients with idiopathic PH and healthy controls. We also evaluated lung and adipose tissue expression of these mediators in the three most commonly used experimental rodent models of pulmonary hypertension. Circulating levels of FABP-4, FGF-21, and adiponectin were significantly elevated in PH patients compared to controls and the mRNA levels of these regulators and PPARγ were also significantly increased in human PH lungs and in the lungs of rats with experimental PH compared to controls. These findings were coupled with increased levels of adipose tissue mRNA of genes related to glucose uptake, glycolysis, tricarboxylic acid cycle, and fatty acid oxidation in experimental PH. Our results support that metabolic alterations in human PH are recapitulated in rodent models of the disease and suggest that adipose tissue may contribute to PH pathogenesis.
Databáze: OpenAIRE
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