Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward
| Autor: | Noa Peretz-Rivlin, Diptendu Mukherjee, Maya Groysman, Anna Terem, Reut Ashwal-Fluss, Maria del Mar Reus-Garcia, Ami Citri, Ben Jerry Gonzales, Noa Bleistein |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Claustrum Optogenetics Biology Basal Ganglia General Biochemistry Genetics and Molecular Biology Midbrain Mice 03 medical and health sciences 0302 clinical medicine Cocaine Dopamine Uptake Inhibitors Reward Dopamine Salience (neuroscience) medicine Animals Neurons Receptors Dopamine D1 Conditioned place preference Frontal Lobe Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Incentive salience General Agricultural and Biological Sciences Nucleus Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Current Biology |
| ISSN: | 0960-9822 |
| Popis: | The claustrum is a small nucleus, exhibiting vast reciprocal connectivity with cortical, subcortical, and midbrain regions. Recent studies, including ours, implicate the claustrum in salience detection and attention. In the current study, we develop an iterative functional investigation of the claustrum, guided by quantitative spatial transcriptional analysis. Using this approach, we identify a circuit involving dopamine-receptor expressing claustral neurons projecting to frontal cortex necessary for context association of reward. We describe the recruitment of claustral neurons by cocaine and their role in drug sensitization. In order to characterize the circuit within which these neurons are embedded, we apply chemo- and opto-genetic manipulation of increasingly specified claustral subpopulations. This strategy resolves the role of a defined network of claustrum neurons expressing dopamine D1 receptors and projecting to frontal cortex in the acquisition of cocaine conditioned-place preference and real-time optogenetic conditioned-place preference. In sum, our results suggest a role for a claustrum-to-frontal cortex circuit in the attribution of incentive salience, allocating attention to reward-related contextual cues. |
| Databáze: | OpenAIRE |
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