Comparison of antibiotic regimens in preterm premature rupture of membranes: neonatal morbidity and 2-year follow-up of neurologic outcome
| Autor: | Jong-Hwa Kim, Jung-Sun Kim, Kylie Hae-Jin Chang, Hyun Joo Kim, Suk-Joo Choi, Soo-young Oh, Hee Joon Yu, Cheong-Rae Roh, Jeehun Lee |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Fetal Membranes Premature Rupture Time Factors Erythromycin Gestational Age Infant Premature Diseases Chorioamnionitis 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Clarithromycin Infant Mortality medicine Humans 030212 general & internal medicine Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Gestational age Infant Retrospective cohort study medicine.disease Anti-Bacterial Agents Cephalosporins Intraventricular hemorrhage Bronchopulmonary dysplasia Anesthesia Pediatrics Perinatology and Child Health Drug Therapy Combination Female business Premature rupture of membranes Infant Premature medicine.drug Follow-Up Studies |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 30(18) |
| ISSN: | 1476-4954 |
| Popis: | The objective of this study was to compare neonatal morbidity and neurologic outcome at 2 years between groups treated with antibiotics regimens consisting clarithromycin and erythromycin in preterm premature rupture of the membranes (pPROM) patients delivered before 32 weeks of gestation.This was a retrospective study comparing neonatal morbidity as primary outcome measures and the neurological outcome at 2 years as secondary outcome.A total of 166 women were included: 80 treated with erythromycin and 86 treated with clarithromycin. The median gestational age at delivery was greater in clarithromycin group (p = 0.005). There was no significant difference in latency (p = 0.77). The incidence of histological chorioamnionitis was significantly lower in clarithromycin group (p = 0.004). By multivariable analysis adjusting confounding variables, the incidence of bronchopulmonary dysplasia and intraventricular hemorrhage (≥Grade 3) was lower in clarithromycin group (BPD; OR 0.34, 95% CI [0.13-0.90]), IVH; OR 0.23, 95% CI [0.06-0.91], respectively). Other morbidities and neurologic outcome at 2 years' corrected age showed no statistically significant difference between two groups.We suggest that clarithromycin-based regimen may be worth considering as an alternative choice of erythromycin in pPROM patients. |
| Databáze: | OpenAIRE |
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