From patients with arthralgia, pre-RA and recently diagnosed RA: what is the current status of understanding RA pathogenesis?
| Autor: | Erik Lubberts, Johanna M. W. Hazes, Marlieke Molendijk |
|---|---|
| Přispěvatelé: | Rheumatology |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chemokine medicine.medical_treatment Immunology early rheumatoid arthritis Rheumatoid Arthritis Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology medicine Immunology and Allergy In patient Bone damage 030203 arthritis & rheumatology biology business.industry Autoantibody medicine.disease cytokines 030104 developmental biology Cytokine inflammation Rheumatoid arthritis biology.protein business |
| Zdroj: | RMD Open, 4(1):UNSP e000256. BMJ Publishing Group RMD Open |
| ISSN: | 2056-5933 |
| Popis: | It is believed that therapy for rheumatoid arthritis (RA) is the most effective and beneficial within a short time frame around RA diagnosis. This insight has caused a shift from research in patients with established RA to patients at risk of developing RA and recently diagnosed patients. It is important for improvement of RA therapy to understand when and what changes occur in patients developing RA. This is true for both seropositive and seronegative patients. Activation of the immune system as presented by autoantibodies, increased cytokine and chemokine production, and alterations within several immune cells occur during RA development. In this review we describe RA pathogenesis with a focus on knowledge obtained from patients with arthralgia, pre-RA and recently diagnosed RA. Connections are proposed between altered immune cells, cytokines and chemokines, and events like synovial hyperplasia, pain and bone damage. |
| Databáze: | OpenAIRE |
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