Preoperative axillary nodal staging of invasive lobular breast cancer with ultrasound guided fine needle aspiration in patients with suspicious ultrasound findings versus aspiration in all patients – A retrospective single institutional analysis
| Autor: | M. Sinkó, Gábor Cserni, O. Serfőző, P. Serényi, István Sejben, Rita Bori, L. Venczel, Tibor Nyári, Erika Csörgő, Róbert Maráz, Tamás Zombori, Éva Ambrózay, K. Lóránd, N. Szeleczki |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Biopsy Fine-Needle Breast Neoplasms Nodal staging Breast cancer Humans Medicine In patient Ultrasonography Interventional Neoplasm Staging Retrospective Studies medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Ultrasound General Medicine medicine.disease Ultrasound guided Fine-needle aspiration Oncology Lymphatic Metastasis Axilla Female Surgery Lymph Nodes Radiology business |
| Zdroj: | European Journal of Surgical Oncology. 48:742-747 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2021.11.130 |
| Popis: | At present, surgical strategies for breast cancer patients with2 lymph nodes (LN) involved differ from those with no or lower degree of nodal involvement. Preoperative assessment of the axilla is less sensitive in patients with lobular carcinoma (ILC) than patients with other histological tumour types.- A retrospective analysis of axillary staging by palpation, axillary ultrasound (AXUS) and AXUS-guided fine-needle aspiration cytology (FNAC) of 153 patients with ILC diagnosed and operated on between January 2013 and December 2020 was performed. Patients had either sentinel node biopsy or axillary lymph node dissection according to current practice. In period 1, patients had FNAC only when AXUS suggested nodal involvement (n = 106), and in period 2, all ILC patients had axillary FNAC (n = 47).- Of the factors associated with2LNs involvement, logistic regression suggested only AXUS/FNAC based staging as independent variable for all patients. Patients with AXUS-guided FNAC had a significantly higher proportion of true negative and lower proportion of true positive cases in the P2 period (0 vs 55% and 72% vs 11% for2 LNs involvement, respectively; both p 0.0001).- AXUS-guided FNAC of all ILC patients did not result in improved preoperative identification of patients with2 metastatic LNs but increased the false-negative rate of the assessment by producing false-negative results in patients who would not have undergone a biopsy due to negative AXUS findings. |
| Databáze: | OpenAIRE |
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