Protein gene product 9.5-immunoreactive retinal neurons in normal developing rats and rats with optic nerve or tract lesion
| Autor: | L.J. Garey, S.T. Chen, K.A. von Bussmann, L.S. Jen |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Optic tract Population Biology Retina Rats Sprague-Dawley Lesion Embryonic and Fetal Development Developmental Neuroscience Reference Values medicine Animals Visual Pathways education Ganglion cell layer Neurons education.field_of_study Optic Nerve Embryo Mammalian Inner plexiform layer Immunohistochemistry Rats medicine.anatomical_structure Inner nuclear layer Optic nerve Female Thiolester Hydrolases sense organs medicine.symptom Ubiquitin Thiolesterase Developmental Biology |
| Zdroj: | Developmental Brain Research. 78:265-272 |
| ISSN: | 0165-3806 |
| DOI: | 10.1016/0165-3806(94)90035-3 |
| Popis: | The present immunocytochemical study indicates that protein gene product 9.5 (PGP 9.5) in the rat retina first appears in a population of neurons in the inner and central part of the neuroblast layer at embryonic day (E) 14. Presumptive horizontal cells which are PGP 9.5 positive were observed at E17. At birth, cells in the inner nuclear layer and ganglion cell layer (GCL) as well as the inner plexiform layer (IPL) were positive. Further differentiation, particularly the appearance and the formation of immunoreactive sublaminae in the IPL, was observed in the first 2 postnatal weeks. This pattern reached adult levels by postnatal day 14. In rats with unilateral neonatal optic tract lesion or optic nerve transection as young adults, 43–45% of the immunoreactive cells were lost in the GCL. However, only minor changes were detected in the IPL, suggesting that amacrine cells contribute mainly to the PGP 9.5 immunoreactivity in this laminar zone of the retina. |
| Databáze: | OpenAIRE |
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