Hypogammaglobulinemia after cardiopulmonary bypass in infants

Autor: Leslie A. Rhodes, T. Prescott Atkinson, Stephen M. Robert, Jeffrey A. Alten, Robert J. Dabal, Alla M. Mahdi
Rok vydání: 2014
Předmět:
Heart Defects
Congenital
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Time Factors
Secondary infection
medicine.medical_treatment
Immunoglobulins
Article
Peritoneal dialysis
law.invention
Capillary Permeability
Hypogammaglobulinemia
Agammaglobulinemia
Risk Factors
law
Intensive Care Units
Neonatal
medicine
Cardiopulmonary bypass
Humans
Retrospective Studies
Cross Infection
Cardiopulmonary Bypass
business.industry
Incidence
Infant
Newborn
Acute Kidney Injury
Length of Stay
Water-Electrolyte Balance
medicine.disease
Respiration
Artificial
Surgery
Cardiac surgery
Systemic inflammatory response syndrome
Treatment Outcome
surgical procedures
operative
Anesthesia
Alabama
Coronary care unit
Cytokines
Female
Fresh frozen plasma
Inflammation Mediators
Cardiology and Cardiovascular Medicine
business
Biomarkers
circulatory and respiratory physiology
Zdroj: The Journal of Thoracic and Cardiovascular Surgery. 147:1587-1593.e1
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2013.07.040
Popis: BackgroundHypogammaglobulinemia has been reported after cardiac surgery and may be associated with adverse outcomes. We sought to define baseline immunoglobulin (Ig) concentration in neonates and infants with congenital heart disease, determine their course after cardiopulmonary bypass (CPB), and determine if post-CPB hypogammaglobulinemia was associated with increased morbidity.MethodsThis was a single-center, retrospective analysis of infants who underwent cardiac surgery with CPB between June 2010 and December 2011. The Ig concentration was obtained from banked plasma of 47 patients from a prior study (pre-CPB, immediately post-CPB, and 24 and 48 hours post-CPB). In addition, any Ig levels drawn for clinical purposes after CPB were included. Ig levels were excluded if drawn after chylothorax diagnosis or intravenous IgG administration.ResultsThe median age was 7 days. Preoperative Ig concentration was similar to that described in healthy children. IgG level decreased to less than 50% of preoperative concentration by 24-hour post-CPB and failed to recover by 7 days. Of 47 patients, 25 (53%) had low IgG (
Databáze: OpenAIRE
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