Sjögren Syndrome in the Intensive Care Unit
| Autor: | Jhon H Quintana, Felipe Rosero, Ingrid Ruiz-Ordoñez, Alejandro Padilla-Guzmán, Anggie Gallego, Ana Suárez-Avellaneda, Cristian C. Aragón, Gabriel J. Tobón |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment MEDLINE Colombia Single Center law.invention 03 medical and health sciences 0302 clinical medicine Rheumatology Interquartile range law medicine Humans Hospital Mortality 030212 general & internal medicine APACHE Retrospective Studies 030203 arthritis & rheumatology Mechanical ventilation business.industry Medical record Retrospective cohort study Prognosis Intensive care unit Intensive Care Units Sjogren's Syndrome Emergency medicine Observational study business |
| Zdroj: | JCR: Journal of Clinical Rheumatology. 26:S174-S179 |
| ISSN: | 1536-7355 1076-1608 |
| DOI: | 10.1097/rhu.0000000000001335 |
| Popis: | Background/objective Studies on the clinical characteristics, prognosis, and factors associated with mortality in patients with Sjogren syndrome (SS), particularly those in the intensive care unit (ICU), are limited. The present study aimed to describe clinical and immunological variables associated with mortality in patients with SS admitted to ICU at a single center in Cali, Colombia. Methods An observational, medical records review study was performed between 2011 and 2019 by reviewing the clinical records of patients with SS admitted to ICU at a high-complexity center. Results Seventy-two patients were included with a total of 117 ICU admissions (17 cases required readmission and 1 case required 17 readmissions): 103 (86.32%) were attributable to medical issues, and 14 corresponded to surgical admissions. Major causes of ICU medical admission were infection (44/103) followed by organ involvement. Only 5 admissions were related to SS due to neurological involvement. The APACHE (Acute Physiology, Age, and Chronic Health Evaluation) score was 10 (interquartile range [IQR], 7-16), the SOFA (Sequential Organ Failure Assessment) score was 2 (IQR, 0-14), and the EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI) score was 0 (IQR, 0-12) with higher values in the nonsurvivor group. Intensive care unit mortality was 12/72 (16.67%). Conclusions The main cause of ICU admission was infection. Patients with increased medical requirements, such as mechanical ventilation and vasopressor support, and with higher APACHE, SOFA, and ESSDAI scores were more susceptible to poor outcomes. Moreover, 50% of deaths were attributable to SS and 25% to infection. |
| Databáze: | OpenAIRE |
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