Resveratrol alleviates ethanol-induced neuroinflammation in vivo and in vitro: Involvement of TLR2-MyD88-NF-κB pathway
| Autor: | Baoning Qi, Juntian Liu, Chuandao Shi, Juanjuan Meng, Shouzhu Xu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system Resveratrol Pharmacology Biochemistry Neuroprotection Proinflammatory cytokine Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Central Nervous System Diseases mental disorders medicine Animals reproductive and urinary physiology Neuroinflammation Memory Disorders Microglia Ethanol Neurotoxicity NF-kappa B NF-κB Cell Biology medicine.disease Toll-Like Receptor 2 Rats 030104 developmental biology medicine.anatomical_structure Neuroprotective Agents chemistry Myeloid Differentiation Factor 88 Tumor necrosis factor alpha 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | The international journal of biochemistrycell biology. 103 |
| ISSN: | 1878-5875 |
| Popis: | Excessive ethanol (EtOH) intake affects cognitive function and leads to permanent learning and memory deficits. EtOH-induced neuroinflammation plays an important role in EtOH neurotoxicity. Studies have shown that EtOH activates microglia and induces an inflammatory response. Resveratrol (Rsv) is a natural polyphenol found in a wide variety of plants and fruits, and produces the neuroprotective and anti-inflammatory effects in the central nervous system. However, effect of Rsv on EtOH-induced neuroinflammation is still unknown. We investigated the anti-inflammatory effect of Rsv in the context of EtOH-induced neurotoxicity and the molecular mechanisms potentially involved in the effect. The results showed that treatment of rats with Rsv prevented the deficits of spatial reference memory induced by EtOH and mitigated EtOH-induced neuroinflammation by inhibiting microglial activation and decreasing the levels of inflammatory cytokines including interleukin-1β, interleukin-6 and tumor necrosis factor α. The further studies indicated that Rsv reduced TLR2 expression in vivo and in vitro, and downregulated expression of myeloid differentiation primary response 88 (MyD88) and phosphorylation of nuclear factor κB (NF-κB). These data demonstrate that Rsv alleviates the ethanol-induced neuroinflammation via inhibition of TLR2-MyD88-NF-κB signal pathway. |
| Databáze: | OpenAIRE |
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