Impairments of speech fluency in Lewy body spectrum disorder
| Autor: | Sharon Ash, Ashley Boller, Andrew Siderowf, Philip A. Cook, Corey T. McMillan, Delani Gunawardena, Rachel G. Gross, Brianna Morgan, Murray Grossman |
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| Rok vydání: | 2012 |
| Předmět: |
Lewy Body Disease
Male Linguistics and Language medicine.medical_specialty Speech production Parkinson's disease Cognitive Neuroscience Prefrontal Cortex Experimental and Cognitive Psychology Neuropsychological Tests Audiology Article Speech Disorders Language and Linguistics Speech and Hearing Fluency Speech Production Measurement otorhinolaryngologic diseases medicine Humans Speech Dementia Connected speech Aged Aged 80 and over Narration Lewy body Dementia with Lewy bodies Linguistics Parkinson Disease Middle Aged medicine.disease Corpus Striatum Female Psychology Cognitive psychology |
| Zdroj: | Brain and Language. 120:290-302 |
| ISSN: | 0093-934X |
| Popis: | Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured narrative speech sample in order to characterize impairments of speech fluency and to determine the factors contributing to reduced speech fluency in these patients. Both demented and non-demented PD patients exhibited reduced speech fluency, characterized by reduced overall speech rate and long pauses between sentences. Reduced speech rate in LBSD correlated with measures of between-utterance pauses, executive functioning, and grammatical comprehension. Regression analyses related non-fluent speech, grammatical difficulty, and executive difficulty to atrophy in frontal brain regions. These findings indicate that multiple factors contribute to slowed speech in LBSD, and this is mediated in part by disease in frontal brain regions. |
| Databáze: | OpenAIRE |
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