Oxygenated C17 polyacetylene metabolites from Algerian Eryngium tricuspidatum L. roots: Structure and biological activity
| Autor: | Fatma Bitam, Margaux Colin, Marianna Carbone, Maria Letizia Ciavatta, Véronique Mathieu, Margherita Gavagnin, A Djebara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Stereochemistry
Monoterpene Antiproliferative activity Secondary metabolite Pharmacologie 01 natural sciences chemistry.chemical_compound Falcarindiol Eryngium Drug Discovery medicine Petroleum ether Eryngium tricuspidatum: Apiaceae Pharmacology biology 010405 organic chemistry Absolute configuration Biological activity General Medicine biology.organism_classification Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Apiaceae [Eryngium tricuspidatum] Polyacetylenes medicine.drug |
| Zdroj: | Fitoterapia (Milano. 1934) 138 (2019): 104355. doi:10.1016/j.fitote.2019.104355 info:cnr-pdr/source/autori:Djebara A.; Ciavatta M.L.; Mathieu V.; Colin M.; Bitam F.; Carbone M.; Gavagnin M./titolo:Oxygenated C17 polyacetylene metabolites from Algerian Eryngium tricuspidatum L. roots: Structure and biological activity/doi:10.1016%2Fj.fitote.2019.104355/rivista:Fitoterapia (Milano. 1934)/anno:2019/pagina_da:104355/pagina_a:/intervallo_pagine:104355/volume:138 Fitoterapia, 138 |
| DOI: | 10.1016/j.fitote.2019.104355 |
| Popis: | The secondary metabolite pattern of Eryngium tricuspidatum has been found to be dominated by C17 acetylene oxylipins, according to the chemistry reported in the literature for the genus Eryngium. Two new oxylipins, 11-acetoxy-falcarindiol (4) and 1,2-dihydro-11-acetoxy-falcarindiol (5) have been isolated, along with main related polyacetylenes 1–3 and the already known monoterpene aldehydes 6–10, from the petroleum ether extract of roots. The structure and the absolute configuration of compounds 4 and 5 have been determined by spectroscopic methods as well as by comparison with related known compounds. Polyacetylenes 1–4 inhibited significantly the in vitro growth of a series of cancer cell lines, ranging from 0.3 to 29 μM, whereas 5 was inactive. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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