Effects of the 5-HT2 receptor antagonist, ritanserin, on biogenic amines in the rat nucleus accumbens
| Autor: | Leslie L. Devaud, Elizabeth B. Hollingsworth |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis Serotonin Dopamine Ritanserin Nucleus accumbens Biology Synaptic Transmission Nucleus Accumbens Piperidines Internal medicine Biogenic amine medicine Animals 5-HT receptor Pharmacology chemistry.chemical_classification 5-HT2 receptor Rats Inbred Strains Rats Endocrinology chemistry Serotonin Antagonists Dialysis medicine.drug Antipsychotic Agents |
| Zdroj: | European journal of pharmacology. 192(3) |
| ISSN: | 0014-2999 |
| Popis: | The effects of acute ritanserin treatment on dopamine (DA) and serotonin (5-HT) release and metabolism were studied in tissue and microdialysis samples of the nucleus accumbens in rats. Administration of a moderate dose of ritanserin elicited decreases in DA and 5-HT in tissue with concomitant increases in extracellular fluid. These data show that selective 5-HT2 receptor antagonism modulates DA as well as 5-HT neurotransmission and adds support to the suggestion that 5-HT/DA interactions may be important in the treatment of psychoses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|